Department of Preventive Medicine and Public Health, Universidade de Santiago de Compostela, Santiago de Compostela, Spain.
CIBEResp, Madrid, Spain.
Obesity (Silver Spring). 2022 Aug;30(8):1659-1669. doi: 10.1002/oby.23480.
The study aimed to identify periods of heightened susceptibility to the effects of pre- and postnatal secondhand tobacco smoke (SHS) exposure on body composition at age 12 years.
The study used data from 217 children from the Health Outcomes and Measures of the Environment (HOME) Study, a prospective cohort in Cincinnati, Ohio. Using multiple informant models, the study estimated associations of maternal serum cotinine (16 and 26 weeks of pregnancy) and child serum cotinine concentrations (at age 12, 24, 36, and 48 months) with measures of body composition obtained with anthropometry and dual-energy x-ray absorptiometry at 12 years. We examined whether there were differences between these associations for pre- and postnatal exposure periods and potential effect measure modification by sex.
Postnatal cotinine concentrations were associated with higher weight, BMI, body fat and lean mass, waist circumference, and visceral, android, and gynoid fat. Each 10-fold increase in postnatal cotinine was associated with 76% increased risk of overweight or obesity (95% CI: 1.13-2.75). Associations between prenatal concentrations and measures of body composition at 12 years were generally null.
Postnatal exposure to SHS may increase adolescent adiposity and lean mass. Future studies should determine whether early-life exposures to SHS are associated with other cardiometabolic risk markers.
本研究旨在确定在 12 岁时，产前和产后二手烟（SHS）暴露对身体成分影响的易感性增强期。
本研究使用了来自俄亥俄州辛辛那提市健康结果和环境措施（HOME）研究的 217 名儿童的数据，该研究是一个前瞻性队列研究。研究采用多信息源模型，估计了母体血清可替宁（妊娠 16 和 26 周）和儿童血清可替宁浓度（12、24、36 和 48 个月时）与 12 岁时通过人体测量法和双能 X 射线吸收法获得的身体成分测量值之间的相关性。我们还研究了这些与产前和产后暴露期之间的差异以及性别对潜在效应测量的影响。
产后可替宁浓度与更高的体重、BMI、体脂肪和瘦体重、腰围以及内脏脂肪、腹型脂肪和臀型脂肪有关。产后可替宁浓度每增加 10 倍，超重或肥胖的风险就增加 76%（95%CI：1.13-2.75）。产前浓度与 12 岁时身体成分测量值之间的相关性一般为零。
产后暴露于 SHS 可能会增加青少年肥胖和瘦体重。未来的研究应该确定儿童早期暴露于 SHS 是否与其他心血管代谢风险标志物有关。
