State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, Wuxi, 214122, China.
Department of Food Science and Technology, College of Light Industry and Food Engineer, Nanjing Forestry University, Nanjing, 210037, China.
Mol Nutr Food Res. 2022 Sep;66(18):e2200225. doi: 10.1002/mnfr.202200225. Epub 2022 Aug 3.
Highland barley tea is a kind of caffeine-free cereal tea. Previous studies have shown that it is rich in polyphenol flavonoids. Here, the effect of Highland barley tea polyphenols (HBP) on the production of advanced glycosylation end-products and alleviate the skeletal muscle damage is systematically investigated.
HBP effectively inhibits the formation of AGEs in vitro, and 12 phenolic compounds are identified. In addition, d-galactose is used to construct a mouse senescence model and intervenes with different doses of HBP. It is found that high doses of HBP effectively inhibit AGEs in serum and flounder muscle species and increased muscle mass in flounder muscle; also, high doses of HBP increase the expression of the mitochondrial functional protein SIRT3 and decrease the expression of myasthenia-related proteins. Furthermore, cellular experiments show that AGEs can significantly increase oxidative stress in skeletal muscle.
These data indicate that the relationship between the biological activity and HBP properties is relevant since Highland barley can be a potential functional food to prevent AGEs-mediated skeletal muscle damage.
青稞茶是一种无咖啡因的谷物茶。先前的研究表明，它富含多酚类黄酮。在这里，系统研究了青稞茶多酚（HBP）对晚期糖基化终产物产生的影响以及减轻骨骼肌损伤的作用。
HBP 可有效抑制体外 AGEs 的形成，并鉴定出 12 种酚类化合物。此外，使用半乳糖构建小鼠衰老模型，并以不同剂量的 HBP 进行干预。结果发现，高剂量的 HBP 可有效抑制血清和比目鱼肌肉中 AGEs 的形成，并增加比目鱼肌肉的质量；此外，高剂量的 HBP 增加了线粒体功能蛋白 SIRT3 的表达，降低了与肌无力相关的蛋白质的表达。此外，细胞实验表明，AGEs 可显著增加骨骼肌的氧化应激。
这些数据表明，青稞的生物活性与其特性之间存在相关性，因为青稞可能是一种预防 AGEs 介导的骨骼肌损伤的潜在功能性食品。
