Borthakur Ishani, Kumari Saloni, Kundu Sabuj
Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, Uttar Pradesh (U.P.), India.
Dalton Trans. 2022 Aug 16;51(32):11987-12020. doi: 10.1039/d2dt01060g.
The long-established practice of using organic solvents in synthetic chemistry is currently becoming a major focus of environmental alarms as many of the chemical wastes are generated in the form of organic solvents. Recently, various alternative solvents have been recognized by the scientific community, including water, ionic liquids, supercritical fluids, glycerol, polyethylene glycol, . Among these alternatives, water is unquestionably an ideal solvent as it is abundant, cheap, non-toxic, and non-flammable. In the last few decades, a breakthrough has been achieved in the field of transition metal-catalyzed dehydrogenation of alcohols and the related chemistry for the sustainable synthesis of a wide range of valuable compounds. Although a large number of reports with new potential are published every year following this alcohol dehydrogenation strategy, the utilization of water as a solvent in alcohol dehydrogenation and related coupling reactions is yet to be highlighted properly. This review summarizes the advances in metal-catalyzed dehydrogenative functionalization of alcohols using water as a solvent.
在合成化学中使用有机溶剂的长期做法目前正成为环境警报的主要焦点，因为许多化学废物是以有机溶剂的形式产生的。最近，科学界已经认识到各种替代溶剂，包括水、离子液体、超临界流体、甘油、聚乙二醇等。在这些替代品中，水无疑是一种理想的溶剂，因为它丰富、廉价、无毒且不易燃。在过去几十年中，过渡金属催化的醇脱氢领域以及用于可持续合成各种有价值化合物的相关化学领域取得了突破。尽管每年都有大量关于这种醇脱氢策略的具有新潜力的报告发表，但水作为醇脱氢及相关偶联反应溶剂的应用尚未得到充分重视。本综述总结了以水为溶剂的金属催化醇脱氢官能化的研究进展。
