亚硝酸丁酯引发自由基级联反应，通过一锅多组分策略合成异恶唑。
-Butyl nitrite triggered radical cascade reaction for synthesizing isoxazoles by a one-pot multicomponent strategy.
机构信息
Key Laboratory of Xin'an Medicine of the Ministry of Education, Anhui University of Chinese Medicine, Hefei, 230038, P. R. China.
Institute of Pharmaceutical Chemistry, Anhui Academy of Chinese Medicine, Hefei, 230038, P. R. China.
出版信息
Chem Commun (Camb). 2022 Aug 11;58(65):9152-9155. doi: 10.1039/d2cc02823a.
A metal-free radical cyclization/dehydrogenation cascade of alkenes with aldehydes has been developed for the synthesis of 3,5-disubstituted isoxazoles in a one-pot system. This protocol features excellent functional group tolerance and operational simplicity, and is easily scaled up. The radical process is well supported by TEMPO-adducts and the intermediate β-carbonyl ketoxime.
一种无金属自由基环化/脱氢级联反应已经被开发出来，用于在一锅体系中合成 3,5-二取代异恶唑。该方法具有良好的官能团容忍性和操作简单性，并且易于放大。自由基过程得到了 TEMPO-加合物和中间β-羰基酮肟的很好支持。
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