通过芳基硫代二氟甲基自由基引发的烯烃串联反应实现硫代色满和 - 芳基丁酰胺的发散式构建
Divergent Construction of Thiochromanes and -Arylbutanamides via Arylthiodifluoromethyl Radical-Triggered Cascade of Alkenes.
作者信息
Sun Yu, Zhang Shu-Peng, Yang Wen-Chao
机构信息
Guangling College and School of Plant Protection, Yangzhou University, Yangzhou 225009, P. R. China.
National Engineering Research Center of Low-Carbon Processing and Utilization of Forest Biomass, Nanjing Forestry University, Nanjing 210037, China.
出版信息
J Org Chem. 2023 Sep 15;88(18):13279-13290. doi: 10.1021/acs.joc.3c01576. Epub 2023 Aug 31.
A strategy utilizing silver-catalyzed oxidative decarboxylation radical cascade cyclization of arylthiodifluoroacetic acids with alkenes for the simple and efficient preparation of difluoromethylated thiochromanes and 2,2-disubstituted--arylbutanamides derivatives has been developed. This approach includes good functional group tolerance, easily accessible starting materials, and operational simplicity.
已开发出一种策略，该策略利用芳基硫代二氟乙酸与烯烃的银催化氧化脱羧自由基级联环化反应，用于简单高效地制备二氟甲基化硫代色满和2,2-二取代的芳基丁酰胺衍生物。这种方法具有良好的官能团耐受性、易于获得的起始原料和操作简便性。
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