Wang Chenglong, Wu Xianqing, Li Haiyan, Qu Jingping, Chen Yifeng
Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China.
Angew Chem Int Ed Engl. 2022 Sep 19;61(38):e202210484. doi: 10.1002/anie.202210484. Epub 2022 Aug 16.
A nickel-catalyzed three-component carbonylative cross-coupling reaction of allylic alcohols and organoalanes with CO at atmospheric pressure is reported, enabling the expedient formation of β,γ-unsaturated ketones with broad scope. Particularly, the chemoselective allylic carbonylation of diols further highlights the practicability of this protocol. The leverage of organoalanes as both the coupling components and the activators for the alcohol functionalization is crucial for this method, thus no extraneous activators are required.
报道了一种镍催化的烯丙醇和有机铝化合物在大气压下与CO的三组分羰基化交叉偶联反应，可便捷地形成具有广泛底物范围的β,γ-不饱和酮。特别地，二醇的化学选择性烯丙基羰基化进一步突出了该方法的实用性。将有机铝化合物用作偶联组分和醇官能化的活化剂对该方法至关重要，因此无需额外的活化剂。
