Bahloul Mabrouk, Kharrat Sana, Makni Saba, Baccouche Najeh, Ammar Rania, Eleuch Aida, Berrajah Lamia, Chtourou Amel, Turki Olfa, Ben Hamida Chokri, Chelly Hedi, Chtara Kamilia, Ayedi Fatma, Bouaziz Mounir
Department of Intensive Care, Habib Bourguiba University Hospital, and University of Sfax, Sfax, Tunisia.
Biochemistry Laboratory, Habib Bourguiba Hospital, and University of Sfax, Sfax, Tunisia.
Am J Trop Med Hyg. 2022 Jul 25;107(3):534-9. doi: 10.4269/ajtmh.21-0934.
We evaluated the prognostic value of serum cholinesterase (SChE) levels in SARS-CoV-2-infected patients requiring intensive care unit (ICU) admission. This is a retrospective study of severe, critically ill, adult COVID-19 patients, all of whom had a confirmed SARS-CoV-2 infection and were admitted into the ICU of a university hospital. We included all patients admitted to our ICU and whose SChE levels were explored on ICU admission and during ICU stay. One hundred and thirty-seven patients were included. There were 100 male and 37 female patients. The mean of SChE activity on ICU admission was 5,656 ± 1,818 UI/L (range: 1926-11,192 IU/L). The SChE activity on ICU admission was significantly lower in nonsurvivors (P < 0.001). A significant association between the SChE activity on ICU admission and the need for invasive mechanical ventilation was found. We also found a significant correlation between the SChE activity and other biomarkers of sepsis (C-reactive protein, procalcitonin, and leukocytes) on ICU admission and during the ICU stay. A significant correlation among SChE nadir value activity recorded during ICU stay, the occurrence of nosocomial infection, and the outcome of studied patients was found. Our study shows that the low SChE activity value is associated with a severe outcome. It might be used as a biomarker to aid in prognostic risk stratification in SARS-CoV-2-infected patients. Further studies for external validation of our findings are needed on this subject.
我们评估了血清胆碱酯酶（SChE）水平对需要入住重症监护病房（ICU）的新型冠状病毒2型（SARS-CoV-2）感染患者的预后价值。这是一项针对重症、危重症成年新冠肺炎患者的回顾性研究，所有患者均确诊感染SARS-CoV-2，并入住一所大学医院的ICU。我们纳入了所有入住我们ICU且在入住ICU时及住院期间检测了SChE水平的患者。共纳入137例患者，其中男性100例，女性37例。入住ICU时SChE活性的平均值为5656±1818 UI/L（范围：1926 - 11192 IU/L）。非存活者入住ICU时的SChE活性显著降低（P < 0.001）。发现入住ICU时的SChE活性与有创机械通气需求之间存在显著关联。我们还发现入住ICU时及住院期间SChE活性与脓毒症的其他生物标志物（C反应蛋白、降钙素原和白细胞）之间存在显著相关性。发现住院期间记录的SChE最低点活性、医院感染的发生与研究患者的预后之间存在显著相关性。我们的研究表明，低SChE活性值与严重预后相关。它可能用作一种生物标志物，以帮助对SARS-CoV-2感染患者进行预后风险分层。关于这一主题，需要进一步研究以对我们的发现进行外部验证。
