Bahloul Mabrouk, Kharrat Sana, Chtara Kamilia, Hafdhi Malek, Turki Olfa, Baccouche Najeh, Ammar Rania, Kallel Nozha, Hsairi Majdi, Chakroun-Walha Olfa, Hamida Chokri Ben, Chelly Hedi, Mahfoudh Khaiereddine Ben, Karoui Abelhamid, Karray Hela, Rekik Noureddine, Bouaziz Mounir
Department of Intensive Care, Habib Bourguiba University Hospital, Sfax University, Sfax, Tunisia.
Department of Radiology, Habib Bourguiba University Hospital, Sfax University, Sfax, Tunisia.
Acute Crit Care. 2022 Feb;37(1):84-93. doi: 10.4266/acc.2021.00129. Epub 2021 Nov 16.
Africa, like the rest of the world, has been impacted by the coronavirus disease 2019 (COVID-19) pandemic. However, only a few studies covering this subject in Africa have been published.
We conducted a retrospective study of critically ill adult COVID-19 patients-all of whom had a confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection- admitted to the intensive care unit (ICU) of Habib Bourguiba University Hospital (Sfax, Tunisia).
A total of 96 patients were admitted into our ICU for respiratory distress due to COVID-19 infection. Mean age was 62.4±12.8 years and median age was 64 years. Mean arterial oxygen tension (PaO2)/fractional inspired oxygen (FiO2) ratio was 105±60 and ≤300 in all cases but one. Oxygen support was required for all patients (100%) and invasive mechanical ventilation for 38 (40%). Prone positioning was applied in 67 patients (70%). Within the study period, 47 of the 96 patients died (49%). Multivariate analysis showed that the factors associated with poor outcome were the development of acute renal failure (odds ratio [OR], 6.7; 95% confidence interval [CI], 1.75-25.9), the use of mechanical ventilation (OR, 5.8; 95% CI, 1.54-22.0), and serum cholinesterase (SChE) activity lower than 5,000 UI/L (OR, 5.0; 95% CI, 1.34-19).
In this retrospective cohort study of critically ill patients admitted to the ICU in Sfax, Tunisia, for acute respiratory failure following COVID-19 infection, the mortality rate was high. The development of acute renal failure, the use of mechanical ventilation, and SChE activity lower than 5,000 UI/L were associated with a poor outcome.
与世界其他地区一样，非洲也受到了2019冠状病毒病（COVID-19）大流行的影响。然而，在非洲，仅有少数关于该主题的研究发表。
我们对入住哈比卜·布尔吉巴大学医院（突尼斯斯法克斯）重症监护病房的成年COVID-19危重症患者进行了一项回顾性研究，所有患者均确诊感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）。
共有96例因COVID-19感染导致呼吸窘迫的患者入住我们的重症监护病房。平均年龄为62.4±12.8岁，中位年龄为64岁。除1例患者外，所有患者的平均动脉血氧分压（PaO2）/吸入氧分数（FiO2）比值为105±60且≤300。所有患者（100%）均需要氧疗，38例（40%）需要有创机械通气。67例患者（70%）采用了俯卧位通气。在研究期间，96例患者中有47例死亡（49%）。多因素分析显示，与预后不良相关的因素包括急性肾衰竭的发生（比值比[OR]，6.7；95%置信区间[CI]，1.75-25.9）、机械通气的使用（OR，5.8；95%CI，1.54-22.0）以及血清胆碱酯酶（SChE）活性低于5000 UI/L（OR，5.0；95%CI，1.34-19）。
在这项对突尼斯斯法克斯因COVID-19感染后急性呼吸衰竭入住重症监护病房的危重症患者的回顾性队列研究中，死亡率很高。急性肾衰竭的发生、机械通气的使用以及SChE活性低于5000 UI/L与预后不良相关。
