Malaria Research Program, Center for Vaccine Development and Global Health, University of Maryland School of Medicine, Baltimore, Maryland.
Ken and Ruth Davee Department of Neurology, Northwestern University, Chicago, Illinois.
Am J Trop Med Hyg. 2022 Jun 13;107(2):315-319. doi: 10.4269/ajtmh.22-0135. Print 2022 Aug 17.
We used a protein microarray featuring Plasmodium falciparum field variants of a merozoite surface antigen to examine malaria exposure in Malian children with different severe malaria syndromes. Unlike children with cerebral malaria alone or severe malarial anemia alone, those with concurrent cerebral malaria and severe malarial anemia had serologic responses demonstrating a broader prior parasite exposure pattern than matched controls with uncomplicated disease. Comparison of levels of malaria-related cytokines revealed that children with the concurrent phenotype had elevated levels of interleukin (IL)-6, IL-8, and IL-10. Our results suggest that the pathophysiology of this severe subtype is unique and merits further investigation.
我们使用了一种含有恶性疟原虫裂殖子表面抗原的蛋白质微阵列，来检测马里不同严重疟疾综合征儿童的疟疾暴露情况。与单纯脑型疟疾或严重疟疾性贫血的儿童不同，同时患有脑型疟疾和严重疟疾性贫血的儿童的血清学反应表明，他们之前的寄生虫暴露模式比匹配的无并发症疾病对照组更为广泛。比较疟疾相关细胞因子的水平发现，同时患有该综合征的儿童体内白细胞介素 (IL)-6、IL-8 和 IL-10 水平升高。我们的结果表明，这种严重亚型的病理生理学是独特的，值得进一步研究。
