Am J Vet Res. 2022 Jun 13;83(8):ajvr.22.03.0047. doi: 10.2460/ajvr.22.03.0047.
To compare electroretinographic (ERG) responses obtained in dogs before and after oral administration of gabapentin, trazodone, and a combination of both medications.
12 clinically normal dogs.
A short-protocol ERG with 20 minutes of dark adaption was recorded for all dogs to establish baseline ERG responses. Dogs then received gabapentin (approx 30 mg/kg), trazadone (approx 20 mg/kg or approx 5 mg/kg), or a combination of gabapentin (approx 20 mg/kg) and trazodone (approx 5 mg/kg) orally, and the same ERG protocol was repeated 2 hours later. Dogs were given a washout period of at least 1 week between treatments.
a-Wave amplitudes were significantly (P = 0.018) decreased after administration of the combination of gabapentin and trazodone. b-Wave amplitudes were significantly decreased after administration of the 20-mg/kg dose of trazodone (P = 0.006) and after administration of the combination of gabapentin and trazodone (P = 0.002). Heavier dogs that received higher total doses of trazodone had decreases in a-wave amplitude after administration of the 20-mg/kg dose of trazodone and in b-wave amplitude after administration of the 5-mg/kg dose of trazodone.
High doses of trazodone and the combination of gabapentin and trazodone significantly decreased a-wave and b-wave amplitudes in clinically normal dogs. However, the effects on retinal responses had little clinical importance. Therefore, these medications can be used safely in a clinical setting; however, further studies are needed in dogs with retinal disease.
比较犬口服加巴喷丁、曲唑酮和两者联合用药前后视网膜电图（ERG）的反应。
12 只临床正常的狗。
所有狗都进行了 20 分钟暗适应的短方案 ERG，以建立基线 ERG 反应。然后，狗口服给予加巴喷丁（约 30mg/kg）、曲唑酮（约 20mg/kg 或约 5mg/kg）或加巴喷丁（约 20mg/kg）和曲唑酮（约 5mg/kg）联合用药，2 小时后重复相同的 ERG 方案。在治疗之间，狗有至少 1 周的洗脱期。
联合使用加巴喷丁和曲唑酮后，a 波振幅显著降低（P=0.018）。给予 20mg/kg 曲唑酮后 b 波振幅显著降低（P=0.006），给予加巴喷丁和曲唑酮联合用药后 b 波振幅显著降低（P=0.002）。接受较高总剂量曲唑酮的较重狗，在给予 20mg/kg 曲唑酮后 a 波振幅降低，在给予 5mg/kg 曲唑酮后 b 波振幅降低。
高剂量曲唑酮和加巴喷丁与曲唑酮联合使用可显著降低临床正常犬的 a 波和 b 波振幅。然而，对视网膜反应的影响临床意义不大。因此，这些药物在临床环境中可以安全使用；然而，需要对患有视网膜疾病的狗进行进一步的研究。
