Division of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, 259-1193, Japan.
Department of Clinical Health Science, Tokai University School of Medicine, Isehara, Japan.
Sci Rep. 2022 Jul 27;12(1):12797. doi: 10.1038/s41598-022-16875-z.
The prevalence of hepatic cysts in the general population and their natural history are largely unknown. This study aimed to assess the prevalence and natural history of hepatic cysts by investigating health checkup participants. Ultrasonographic data of health checkup participants (n = 38,842) were retrospectively evaluated to calculate its prevalence. In addition, we assessed the changes in the size and characteristics of hepatic cysts over 10 years (n = 7709). We found the prevalence of hepatic cysts was 21.9%. Older age, female sex, and presence of kidney cysts or pancreatic cysts were associated with the occurrence of hepatic cysts. Younger age, female sex, and the existence of multiple hepatic cysts were associated with cyst enlargement. Among 126 individuals who had hepatic cysts with a diameter of 30 mm or larger at the first visit, two (1.6%) required treatment. Remain 124 cases showed four patterns: 44 cases with enlargement, 47 stable, 11 regression after enlargement, and 22 regression. Hyperechoic fluid inside the cysts was observed in 54.5% (18 of 33), which was significantly higher than 6.6% (6 of 91) of the non-regression (OR = 17.0). The appearance of intracystic hyperechoic fluid by ultrasound may predict subsequent regression of the hepatic cyst.
肝囊肿在普通人群中的患病率及其自然史尚不清楚。本研究旨在通过调查健康检查参与者来评估肝囊肿的患病率和自然史。回顾性评估健康检查参与者的超声数据(n=38842)，以计算其患病率。此外，我们还评估了肝囊肿大小和特征在 10 年内的变化(n=7709)。我们发现肝囊肿的患病率为 21.9%。年龄较大、女性、存在肾囊肿或胰腺囊肿与肝囊肿的发生有关。年龄较小、女性和存在多个肝囊肿与囊肿增大有关。在首次就诊时直径为 30mm 或更大的 126 例肝囊肿患者中，有 2 例(1.6%)需要治疗。其余 124 例表现出四种模式：44 例增大，47 例稳定，11 例增大后缩小，22 例缩小后消失。囊肿内出现高回声液的比例为 54.5%(18/33)，明显高于非缩小组的 6.6%(6/91)(OR=17.0)。超声显示囊肿内高回声液可能预示肝囊肿随后会缩小。
