Henkens M T H M, van Ast J F, Te Riele A S J M, Houweling A C, Amin A S, Nijveldt R, Antoni M L, Li X, Wehrens S M T, von der Thüsen J H, Damman K, Ter Horst E N, Manintveld O C, Abma-Schouten R Y, Niessen H W M, Silljé H H W, Jukema J W, Doevendans P A
Netherlands Heart Institute (NLHI), Utrecht, The Netherlands.
Department of Pathology, CARIM, Maastricht University Medical Centre, Maastricht, The Netherlands.
Neth Heart J. 2023 Jan;31(1):16-20. doi: 10.1007/s12471-022-01713-8. Epub 2022 Jul 27.
Cardiac diseases remain a leading cause of cardiovascular disease (CVD) related hospitalisation and mortality. That is why research to improve our understanding of pathophysiological processes underlying cardiac diseases is of great importance. There is a strong need for healthy and diseased human cardiac tissue and related clinical data to accomplish this, since currently used animal and in vitro disease models do not fully grasp the pathophysiological processes observed in humans. This design paper describes the initiative of the Netherlands Heart Tissue Bank (NHTB) that aims to boost CVD-related research by providing an open-access biobank.
The NHTB, founded in June 2020, is a non-profit biobank that collects and stores biomaterial (including but not limited to myocardial tissue and blood samples) and clinical data of individuals with and without previously known cardiac diseases. All individuals aged ≥ 18 years living in the Netherlands are eligible for inclusion as a potential future donor. The stored samples and clinical data will be available upon request for cardiovascular researchers.
To improve the availability of cardiac tissue for cardiovascular research, the NHTB will include extensive (cardiac) biosamples, medical images, and clinical data of donors with and without a previously known cardiac disease. As such, the NHTB will function as a translational bridge to boost a wide range of cardiac disease-related fundamental and translational studies.
心脏疾病仍然是心血管疾病（CVD）相关住院和死亡的主要原因。这就是为什么开展研究以增进我们对心脏疾病潜在病理生理过程的理解至关重要。为实现这一目标，迫切需要健康和患病的人类心脏组织及相关临床数据，因为目前使用的动物和体外疾病模型无法完全把握在人类身上观察到的病理生理过程。本设计文件描述了荷兰心脏组织库（NHTB）的倡议，其旨在通过提供一个开放获取的生物样本库来推动与CVD相关的研究。
NHTB成立于2020年6月，是一个非营利性生物样本库，收集和存储生物材料（包括但不限于心肌组织和血液样本）以及有或无既往已知心脏疾病个体的临床数据。所有年龄≥18岁居住在荷兰的个体都有资格作为潜在的未来捐赠者被纳入。存储的样本和临床数据将应心血管研究人员的要求提供。
为提高用于心血管研究的心脏组织的可及性，NHTB将纳入广泛的（心脏）生物样本、医学图像以及有或无既往已知心脏疾病捐赠者的临床数据。因此，NHTB将作为一座转化桥梁，推动广泛的与心脏疾病相关的基础和转化研究。
Zotero 插件