Institute of Virology, Universitatsklinikum Freiburg, Hermann Herder Strabe, 11, 79104 Freiburg, Germany.
Special Programme for Research & Training in Tropical Diseases (TDR), World Health Organization, Avenue Appia 20, 1211 Geneva 27, Switzerland.
Int J Environ Res Public Health. 2022 Jul 22;19(15):8896. doi: 10.3390/ijerph19158896.
Background: Mosquito-borne infections are of global health concern because of their rapid spread and upsurge, which creates a risk for coinfections. Chikungunya, an arbovirus disease transmitted by Aedes aegypti or A. albopictus, and malaria, a parasitic disease transmitted by Anopheles gambiae, are prevalent in Nigeria and neighbouring countries, but their burden and possible coinfections are poorly understood. In this study, we investigated the seroprevalence, hidden burden and endemicity of chikungunya and malaria in three regions in Nigeria. Methods: A cross-sectional sero-survey was conducted on 871 participants in three regions of Nigeria. The samples were collected from outpatients employing simple random sampling. All serum sample analyses were performed using CHIKV virus-like particle recomLine Tropical Fever for the presence of arboviral antibody serological marker IgG immunoblot for chikungunya and malaria RDT (Rapid Diagnostic Test) for malaria parasites. Results: The seroprevalences of chikungunya and malaria mono-infection were 64.9% and 27.7%, respectively, while the coinfection seroprevalence was 71.9%. The central (69.5%) and northern (67.0%) regions showed more significant seroprevalences than the southern region (48.0%). The seroprevalence and the hidden burden of chikungunya and malaria infections varied across the three geographical regions. Conclusions: This study highlighted an unexpectedly high seroprevalence and hidden endemicity of chikungunya and a less surprising high malaria endemicity in three regions of Nigeria.
蚊媒传染病因其迅速传播和激增而引起全球健康关注，这增加了合并感染的风险。基孔肯雅热是一种由埃及伊蚊或白纹伊蚊传播的虫媒病毒病，疟疾是一种由冈比亚按蚊传播的寄生虫病，这两种疾病在尼日利亚和邻国都很流行，但它们的负担和可能的合并感染情况了解甚少。在这项研究中，我们调查了尼日利亚三个地区基孔肯雅热和疟疾的血清流行率、隐性负担和地方性。
我们在尼日利亚的三个地区进行了一项横断面血清学调查，共有 871 名参与者参与。采用简单随机抽样从门诊患者中采集样本。所有血清样本分析均采用 CHIKV 病毒样颗粒 recomLine 热带热用于存在虫媒病毒抗体血清学标志物 IgG 免疫印迹用于基孔肯雅热和疟疾 RDT（快速诊断测试）用于疟疾寄生虫。
基孔肯雅热和疟疾单感染的血清流行率分别为 64.9%和 27.7%，而合并感染的血清流行率为 71.9%。中部（69.5%）和北部（67.0%）地区的血清流行率高于南部地区（48.0%）。三个地理区域的基孔肯雅热和疟疾感染的血清流行率和隐性负担存在差异。
本研究强调了尼日利亚三个地区基孔肯雅热和疟疾感染的血清流行率和隐性地方性出人意料地高，而疟疾的地方性也很高。
