Mori Yu, Masahashi Naoya, Aizawa Toshimi
Department of Orthopaedic Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.
Institute for Materials Research, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai 980-8577, Japan.
Materials (Basel). 2022 Jul 22;15(15):5116. doi: 10.3390/ma15155116.
Titanium alloys are useful for application in orthopedic implants. However, complications, such as prosthetic infections and aseptic loosening, often occur after orthopedic devices are implanted. Therefore, innovation in surface modification techniques is essential to develop orthopedic materials with optimal properties at the biomaterial-bone interface. In this review, we present recent research on the improvement in the osteoconductivity and antibacterial effect of the Ti-33.6% Nb-4% Sn (TiNbSn) alloy by anodic oxidation and other related studies. TiNbSn alloys are excellent new titanium alloys with a low Young's modulus, high tensile strength, and with gradient functional properties such as a thermally adjustable Young's modulus and strength. Titanium dioxide (TiO), when obtained by the anodic oxidation of a TiNbSn alloy, improves bone affinity and provides antibacterial performance owing to its photocatalytic activity. The safety of TiO and its strong bonding with metal materials make its method of preparation a promising alternative to conventional methods for improving the surface quality of orthopedic implants. Implementing anodization technology for TiNbSn alloys may alleviate orthopedic surgery-related complications, such as loosening, stress shielding, and infection after arthroplasty.
钛合金在骨科植入物应用中很有用。然而，骨科器械植入后常出现并发症，如假体感染和无菌性松动。因此，创新表面改性技术对于开发在生物材料-骨界面具有最佳性能的骨科材料至关重要。在本综述中，我们介绍了通过阳极氧化改善Ti-33.6% Nb-4% Sn（TiNbSn）合金的骨传导性和抗菌效果的最新研究以及其他相关研究。TiNbSn合金是优良的新型钛合金，具有低杨氏模量、高拉伸强度以及热可调杨氏模量和强度等梯度功能特性。通过TiNbSn合金阳极氧化获得的二氧化钛（TiO）可改善骨亲和力，并因其光催化活性而具有抗菌性能。TiO的安全性及其与金属材料的强结合力使其制备方法成为改善骨科植入物表面质量的传统方法的有前景的替代方案。对TiNbSn合金实施阳极氧化技术可能会减轻骨科手术相关并发症，如关节置换术后的松动、应力屏蔽和感染。
