生物活性玻璃（BAG）在牙科复合材料中的应用：一项批判性回顾。
The use of bioactive glass (BAG) in dental composites: A critical review.
机构信息
Queen Mary University of London, Barts & The London School of Medicine and Dentistry, Institute of Dentistry, Centre for Oral Bioengineering, Mile End Road, London E1 4NS, UK.
Queen Mary University of London, Barts & The London School of Medicine and Dentistry, Institute of Dentistry, Centre for Oral Bioengineering, Mile End Road, London E1 4NS, UK.
出版信息
Dent Mater. 2021 Feb;37(2):296-310. doi: 10.1016/j.dental.2020.11.015. Epub 2021 Jan 10.
OBJECTIVE
In recent years, numerous studies have analyzed the role of bioactive glass (BAG) as remineralizing additives in dental restorative composites. This current review provides a critical analysis of the existing literature, particularly focusing on BAGs prepared via the melt-quench route that form an "apatite-like" phase when immersed in physiological-like solutions.
METHODS
Online databases (Science Direct, PubMed and Google Scholar) were used to collect data published from 1962 to 2020. The research papers were analyzed and the relevant papers were selected for this review. Sol-gel BAGs were not included in this review since it is not a cost-effective manufacturing technique that can be upscaled and is difficult to incorporate fluoride.
RESULTS
BAGs release Ca, PO and F ions, raise the pH and form apatite. There are numerous published papers on the bioactivity of BAGs, but the different glass compositions, volume fractions, particle sizes, immersion media, time points, and the characterization techniques used, make comparison difficult. Several papers only use certain characterization techniques that do not provide a full picture of the behavior of the glass. It was noted that in most studies, mechanical properties were measured on dry samples, which does not replicate the conditions in the oral environment. Therefore, it is recommended that samples should be immersed for longer time periods in physiological solutions to mimic clinical environments.
SIGNIFICANCE
BAGs present major benefits in dentistry, especially their capacity to form apatite, which could potentially fill any marginal gaps produced due to polymerization shrinkage.
目的
近年来，大量研究分析了生物活性玻璃（BAG）作为牙齿修复复合材料再矿化添加剂的作用。本综述对现有文献进行了批判性分析，特别是重点分析了通过熔融淬火法制备的 BAG，这些 BAG 在浸入类似生理的溶液中时会形成“类磷灰石”相。
方法
在线数据库（Science Direct、PubMed 和 Google Scholar）用于收集 1962 年至 2020 年发表的数据。分析研究论文，并选择相关论文进行综述。本综述不包括溶胶-凝胶 BAG，因为它不是一种具有成本效益的制造技术，无法放大规模，并且难以掺入氟化物。
结果
BAG 释放 Ca、PO 和 F 离子，提高 pH 值并形成磷灰石。有大量关于 BAG 生物活性的已发表论文，但不同的玻璃成分、体积分数、粒径、浸提介质、时间点以及使用的表征技术使得比较变得困难。有几篇论文仅使用某些表征技术，这些技术无法全面反映玻璃的行为。值得注意的是，在大多数研究中，机械性能是在干燥样品上测量的，这不能复制口腔环境中的条件。因此，建议将样品在生理溶液中浸泡更长时间，以模拟临床环境。
意义
BAG 在牙科中具有重要的优势，特别是其形成磷灰石的能力，这可能会填补由于聚合收缩而产生的任何边缘间隙。
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