Givaudan Active Beauty, R&D, 51110 Pomacle, France.
Givaudan Active Beauty, R&D, 31400 Toulouse, France.
Molecules. 2022 Jul 26;27(15):4769. doi: 10.3390/molecules27154769.
(1) Background: Preclinical studies report that the ethanolic fraction from Mangifera indica leaves is a potential anti-acne agent. Nevertheless, the biological activity of Mangifera indica leaves has scarcely been investigated, and additional data are needed, especially in a clinical setting, for establishing the actual effectiveness of Mangifera indica extract as an active component of anti-acne therapy. (2) Methods: The evaluation of the biological activity of Mangifera indica extract was carried out through different experimental phases, which comprised in silico, in vitro, ex vivo and clinical evaluations. (3) Results: In silico and in vitro studies allowed us to identify the phytomarkers carrying the activity of seboregulation and acne management. Results showed that Mangifera indica extract reduced lipid production by 40% in sebocytes, and an improvement of the sebum quality was reported after the treatment in analyses performed on sebaceous glands from skin explants. The evaluation of the sebum quantity and quality using triglyceride/free fatty acid analysis conducted on Caucasian volunteers evidenced a strong improvement and a reduction of porphyrins expression. The C. acnes lipase activity from a severe acne phylotype was evaluated in the presence of Mangifera indica, and a reduction by 29% was reported. In addition, the analysis of the skin microbiota documented that Mangifera indica protected the microbiota equilibrium while the placebo induced dysbiosis. (4) Conclusions: Our results showed that Mangifera indica is microbiota friendly and efficient against lipase activity of C. acnes and supports a role for Mangifera indica in the therapeutic strategy for prevention and treatment of acne.
（1）背景：临床前研究报告称，芒果叶的乙醇提取物是一种有潜力的抗粉刺剂。然而，芒果叶的生物活性尚未得到充分研究，需要更多的数据，特别是在临床环境中，以确定芒果提取物作为抗粉刺治疗的有效成分的实际效果。（2）方法：通过不同的实验阶段评估芒果提取物的生物活性，包括计算机模拟、体外、离体和临床评估。（3）结果：计算机模拟和体外研究使我们能够识别出具有皮脂调节和粉刺管理活性的植物标志物。结果表明，芒果提取物可使皮脂细胞中的脂质产量减少 40%，并且在对皮肤外植体中的皮脂腺进行的分析中，报告了在治疗后皮脂质量的改善。使用甘油三酯/游离脂肪酸分析对高加索志愿者的皮脂量和质量进行评估，结果表明有明显的改善和减少卟啉的表达。在存在芒果的情况下评估来自严重痤疮表型的 C. acnes 脂肪酶活性，报告减少了 29%。此外，皮肤微生物组分析表明，芒果可保护微生物组平衡，而安慰剂则会导致微生态失调。（4）结论：我们的结果表明，芒果对皮肤微生物组友好且有效，可抑制 C. acnes 的脂肪酶活性，并支持将芒果用于预防和治疗痤疮的治疗策略。
