Salih Abdalrhaman M, Alattas Nada M, Alsubaie Qasi D, Anifowose Saheed O
National Research and Development Center for Sustainable Agriculture (Estidamah), Riyadh Techno Valley, Riyadh 12373, Saudi Arabia.
Botany and Microbiology Department, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Life (Basel). 2025 Mar 18;15(3):489. doi: 10.3390/life15030489.
Pomegranate ( L.) belongs to the Punicaceae family and is native to Central Asia; yet, it has a wide geographical distribution globally, reflecting its adaptation to different climatic conditions. Pomegranate is among the oldest and most significant cultivated crops, thriving extensively in tropical and subtropical climates. Besides its nutritional uses, pomegranate has been employed in traditional medicine for treating various diseases, including cancer prevention, antimicrobial activity, male infertility, ulcers, and diarrhea. The Bidah pomegranate cultivar is known for its unique sweet taste and high productivity yield. However, there is limited knowledge about its nutritional composition and medicinal value. Therefore, this study aimed to evaluate the functional potential of Bidah pomegranate in terms of its phytochemicals, antioxidant capacity, antibacterial, and anticancer activity. Different analytical techniques were used to investigate the chemical composition and antioxidant properties of Bidah pomegranate. Moreover, the biological activity of shoot and callus of Bidah pomegranate cultivar was assessed against (), (), and the colorectal cancer cell line (CaCo-2). Gas chromatography/mass spectrometry (GC/MS) analysis of the shoot and callus extracts revealed about 17 and 18 phytochemical compounds, respectively. Phenolic quantification showed that pomegranate materials contained high amounts of phenolic content. Additionally, Bidah pomegranate cultivar possesses high antioxidant activity with a low half-maximal inhibitory concentration (IC50) value. Furthermore, the pomegranate extract showed promising results with human pathogenic bacteria ( and ), especially against and the colorectal cancer cell line (CaCo-2). The findings of this study support the traditional use of pomegranate in folk medicine and highlight its potential for further exploration as a source of therapeutic agents.
石榴（Punica granatum L.）属于石榴科，原产于中亚；然而，它在全球范围内具有广泛的地理分布，这反映了它对不同气候条件的适应性。石榴是最古老、最重要的栽培作物之一，在热带和亚热带气候中广泛种植。除了其营养用途外，石榴还被用于传统医学中治疗各种疾病，包括预防癌症、抗菌活性、男性不育、溃疡和腹泻。比达石榴品种以其独特的甜味和高产而闻名。然而，关于其营养成分和药用价值的了解有限。因此，本研究旨在评估比达石榴在植物化学物质、抗氧化能力、抗菌和抗癌活性方面的功能潜力。采用不同的分析技术来研究比达石榴的化学成分和抗氧化性能。此外，还评估了比达石榴品种的茎段和愈伤组织对金黄色葡萄球菌（Staphylococcus aureus）、大肠杆菌（Escherichia coli）和结肠癌细胞系（CaCo-2）的生物活性。对茎段和愈伤组织提取物的气相色谱/质谱（GC/MS）分析分别揭示了约17种和18种植物化学化合物。酚类定量分析表明，石榴材料含有大量的酚类物质。此外，比达石榴品种具有高抗氧化活性，半最大抑制浓度（IC50）值较低。此外，石榴提取物对人类病原菌（金黄色葡萄球菌和大肠杆菌），尤其是对金黄色葡萄球菌和结肠癌细胞系（CaCo-2）显示出有前景的结果。本研究的结果支持了石榴在民间医学中的传统用途，并突出了其作为治疗剂来源进一步探索的潜力。
