Cui A L, Zhu Z, Mao N Y, Xie Z B, Guan L Y, Hu K X, Zhu R N, Wu J L, Li Y, Ma Y W, Li F C, Wang W Y, Gao Z G, Zhang Y, Xu Wenbo
NHC Key Laboratory of Medical Virology and Viral Diseases/National Measles Laboratory, National Institute for Viral Disease Control and Prevention, Chinese Centers for Disease Control and Prevention, Beijing 102206, China.
Viral disease department, Shaanxi Center for Disease Control and Prevention, Xi'an 710054, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2022 Jul 6;56(7):912-918. doi: 10.3760/cma.j.cn112150-20220228-00184.
To understand the common viral infection among the surveillance cases of fever respiratory syndrome (FRS) in nine provinces in China. The research data were obtained from nine provinces (Anhui, Beijing, Guangdong, Hebei, Hunan, Jilin, Shandong, Shaanxi and Xinjiang) in the "Infectious Disease Surveillance Technology Platform Information Management System" of the Chinese Center for Disease Control and Prevention from January 2009 to June 2021. Finally, 8 243 FRS cases with nucleic acid detection results of eight viruses [human influenza virus (HIFV), human respiratory syncytial virus (HRSV), human adenovirus (HAdV), human parainfluenza virus (HPIV), human rhinovirus (HRV), human metapneumovirus (HMPV), human coronavirus (HCoV) and human Boca virus (HBoV)] were included in the study. The χ test/Fisher exact probability method was used to analyze the difference of virus detection rate in different age groups, regions and seasons. s The () age of 8 243 FRS cases was 4 (1, 18) years old, and 56.56% (4 662 cases) were children under 5 years old. Males accounted for 58.1% (4 792 cases) of all cases. All cases were from outpatient/emergency department (2 043 cases) and inpatient department (6 200 cases). The virus detection rates of FRS cases from high to low were HRSV, HIFV, HPIV, HRV, HAdV, HMPV, HCoV and HBoV. Two or more viruses were detected simultaneously in 524 cases, accounting for 15.66% of virus-positive cases. The difference of the virus detection rate in different age groups was statistically significant (all values<0.05), and the virus detection rate in children<5 years old was higher (49.96%). The positive rate of any virus in south China was higher than that in north China (<0.001). The virus-positive FRS cases were detected throughout the year. The detection rate of HRSV was higher in autumn and winter. The detection rate of HIFV was higher in winter. The detection rate of HMPV was higher in winter and spring. The detection rates of HPIV, HRV, HCoV and HBoV were higher in summer and autumn, while there was no significant difference in the detection rate of HAdV in different seasons. Compared with 2009-2019, the detection rate of any virus in 2020-2021 decreased from 41.37% to 37.86%. The detection rate of HIFV decreased sharply from 10.62% to 1.37%. The detection rate of HPIV decreased from 8.24% to 5.88%. The detection rate of HRV and HBoV increased from 5.43% and 1.79% to 9.67% and 3.19%, respectively. HRSV and HIFV infections are more common among FRS cases in nine provinces in China from 2009 to 2021, and the epidemiological characteristics of eight common respiratory viruses vary in different age groups, regions and seasons.
了解中国9省发热呼吸道综合征（FRS）监测病例中的常见病毒感染情况。研究数据来源于2009年1月至2021年6月中国疾病预防控制中心“传染病监测技术平台信息管理系统”中的9个省（安徽、北京、广东、河北、湖南、吉林、山东、陕西和新疆）。最终，纳入8243例有8种病毒（人类流感病毒（HIFV）、人类呼吸道合胞病毒（HRSV）、人类腺病毒（HAdV）、人类副流感病毒（HPIV）、人类鼻病毒（HRV）、人类偏肺病毒（HMPV）、人类冠状病毒（HCoV）和人类博卡病毒（HBoV））核酸检测结果的FRS病例。采用χ检验/Fisher确切概率法分析不同年龄组、地区和季节病毒检出率的差异。8243例FRS病例的年龄中位数为4（1，18）岁，5岁以下儿童占56.56%（4662例）。男性占所有病例的58.1%（4792例）。所有病例均来自门诊/急诊科（2043例）和住院部（6200例）。FRS病例的病毒检出率从高到低依次为HRSV、HIFV、HPIV、HRV、HAdV、HMPV、HCoV和HBoV。524例同时检测到两种或以上病毒，占病毒阳性病例的15.66%。不同年龄组的病毒检出率差异有统计学意义（所有P值<0.05），5岁以下儿童的病毒检出率较高（49.96%）。中国南方任何一种病毒的阳性率均高于北方（P<0.001）。全年均有病毒阳性的FRS病例检出。HRSV在秋冬季节检出率较高。HIFV在冬季检出率较高。HMPV在冬春季节检出率较高。HPIV、HRV、HCoV和HBoV在夏秋季节检出率较高，而HAdV在不同季节的检出率无明显差异。与2009 - 2019年相比，2020 - 2021年任何一种病毒的检出率从41.37%降至37.86%。HIFV的检出率从10.62%急剧降至1.37%。HPIV的检出率从8.24%降至5.88%。HRV和HBoV的检出率分别从5.43%和1.79%升至9.67%和3.19%。2009年至2021年，HRSV和HIFV感染在中国9省FRS病例中较为常见，8种常见呼吸道病毒的流行病学特征在不同年龄组、地区和季节有所不同。
