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2019 年至 2022 年期间俄罗斯新西伯利亚儿童急性呼吸道感染病因变化：SARS-CoV-2 病毒的影响。

Changes in the Etiology of Acute Respiratory Infections among Children in Novosibirsk, Russia, between 2019 and 2022: The Impact of the SARS-CoV-2 Virus.

机构信息

Laboratory of Molecular Epidemiology and Biodiversity of Viruses, Federal Research Center of Fundamental and Translational Medicine, Novosibirsk 630060, Russia.

Department of Children's Diseases, Novosibirsk Children's Municipal Clinical Hospital No 6, Novosibirsk 630015, Russia.

出版信息

Viruses. 2023 Apr 9;15(4):934. doi: 10.3390/v15040934.

DOI:10.3390/v15040934
PMID:37112913
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10141072/
Abstract

A wide range of human respiratory viruses are known that may cause acute respiratory infections (ARIs), such as influenza A and B viruses (HIFV), respiratory syncytial virus (HRSV), coronavirus (HCoV), parainfluenza virus (HPIV), metapneumovirus (HMPV), rhinovirus (HRV), adenovirus (HAdV), bocavirus (HBoV), and others. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the COronaVIrus Disease (COVID) that lead to pandemic in 2019 and significantly impacted on the circulation of ARIs. The aim of this study was to analyze the changes in the epidemic patterns of common respiratory viruses among children and adolescents hospitalized with ARIs in hospitals in Novosibirsk, Russia, from November 2019 to April 2022. During 2019 and 2022, nasal and throat swabs were taken from a total of 3190 hospitalized patients 0-17 years old for testing for HIFV, HRSV, HCoV, HPIV, HMPV, HRV, HAdV, HBoV, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by real-time PCR. The SARS-CoV-2 virus dramatically influenced the etiology of acute respiratory infections among children and adolescents between 2019 and 2022. We observed dramatic changes in the prevalence of major respiratory viruses over three epidemic research seasons: HIFV, HRSV, and HPIV mainly circulated in 2019-2020; HMPV, HRV, and HCoV dominated in 2020-2021; and HRSV, SARS-CoV-2, HIFV, and HRV were the most numerous agents in 2021-2022. Interesting to note was the absence of HIFV and a significant reduction in HRSV during the 2020-2021 period, while HMPV was absent and there was a significant reduction of HCoV during the following epidemic period in 2021-2022. Viral co-infection was significantly more frequently detected in the 2020-2021 period compared with the other two epidemic seasons. Certain respiratory viruses, HCoV, HPIV, HBoV, HRV, and HAdV, were registered most often in co-infections. This cohort study has revealed that during the pre-pandemic and pandemic periods, there were dramatic fluctuations in common respiratory viruses registered among hospitalized patients 0-17 years old. The most dominant virus in each research period differed: HIFV in 2019-2020, HMPV in 2020-2021, and HRSV in 2021-2022. Virus-virus interaction was found to be possible between SARS-CoV-2 and HRV, HRSV, HAdV, HMPV, and HPIV. An increase in the incidence of COVID-19 was noted only during the third epidemic season (January to March 2022).

摘要

已知多种人类呼吸道病毒可引起急性呼吸道感染（ARI），例如甲型和乙型流感病毒（HIFV）、呼吸道合胞病毒（HRSV）、冠状病毒（HCoV）、副流感病毒（HPIV）、偏肺病毒（HMPV）、鼻病毒（HRV）、腺病毒（HAdV）、博卡病毒（HBoV）等。严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）导致 2019 年的冠状病毒病（COVID）大流行，对 ARI 的流行情况产生了重大影响。本研究旨在分析 2019 年 11 月至 2022 年 4 月期间，俄罗斯新西伯利亚医院因 ARI 住院的儿童和青少年中常见呼吸道病毒的流行模式变化。在此期间，对来自 3190 名 0-17 岁住院患者的鼻和咽喉拭子进行了 HIFV、HRSV、HCoV、HPIV、HMPV、HRV、HAdV、HBoV 和严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的实时 PCR 检测。SARS-CoV-2 病毒极大地影响了 2019 年至 2022 年儿童和青少年急性呼吸道感染的病因。我们观察到三个流行季节主要呼吸道病毒的流行率发生了显著变化：HIFV、HRSV 和 HPIV 主要在 2019-2020 年流行；HMPV、HRV 和 HCoV 在 2020-2021 年占主导地位；2021-2022 年，HRSV、SARS-CoV-2、HIFV 和 HRV 是最常见的病原体。值得注意的是，HIFV 在 2020-2021 年期间缺失，HRSV 显著减少，而在 2021-2022 年的下一个流行期，HMPV 缺失，HCoV 显著减少。与其他两个流行季节相比，2020-2021 年期间病毒合并感染的检测频率显著更高。某些呼吸道病毒，如 HCoV、HPIV、HBoV、HRV 和 HAdV，在合并感染中经常被检出。这项队列研究表明，在大流行前和大流行期间，0-17 岁住院患者中常见呼吸道病毒的登记存在显著波动。每个研究期的主要病毒不同：2019-2020 年为 HIFV，2020-2021 年为 HMPV，2021-2022 年为 HRSV。发现 SARS-CoV-2 与 HRV、HRSV、HAdV、HMPV 和 HPIV 之间可能存在病毒-病毒相互作用。仅在第三个流行季节（2022 年 1 月至 3 月）观察到 COVID-19 发病率的增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b31/10141072/efe8c9c93f7f/viruses-15-00934-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b31/10141072/a2824d1a31da/viruses-15-00934-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b31/10141072/05d6441a444f/viruses-15-00934-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b31/10141072/335782d1b39a/viruses-15-00934-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b31/10141072/efe8c9c93f7f/viruses-15-00934-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b31/10141072/a2824d1a31da/viruses-15-00934-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b31/10141072/05d6441a444f/viruses-15-00934-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b31/10141072/335782d1b39a/viruses-15-00934-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b31/10141072/efe8c9c93f7f/viruses-15-00934-g004.jpg

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本文引用的文献

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