Li B S, Shi Y, Geng M J, Guo Y Q, Lin F, Zhang Y P, Li Z J, Wang L P
Infectious Disease Prevention and Control Institute of Chongqing Center for Disease Control and Prevention, Chongqing 400000, China Division of Infectious Disease, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases,Chinese Centre for Disease Control and Prevention, Beijing 102206, China.
Division of Infectious Disease, National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases,Chinese Centre for Disease Control and Prevention, Beijing 102206, China.
Zhonghua Yu Fang Yi Xue Za Zhi. 2024 Sep 6;58(9):1311-1317. doi: 10.3760/cma.j.cn112150-20231105-00313.
To analyze the epidemiological characteristics of human respiratory syncytial virus (HRSV) in cases of febrile respiratory syndrome in China from 2010 to 2020. Based on the sub-project of the National Science and Technology Major Project for Infectious Disease Prevention and Control "Infectious Disease Monitoring Technology Platform", active monitoring of febrile respiratory syndrome cases was conducted in sentinel hospitals in 31 provinces across China (excluding Hong Kong, Macau, and Chinese Taiwan) from January 2010 to December 2020, resulting in the inclusion of 191 441 cases. Clinical specimens of monitored cases were screened for HRSV nucleic acid, and the differences in HRSV detection rates among different age groups, regions, and time periods were analyzed using the χ test/Fisher exact probability method. Among the 191 441 cases of febrile respiratory syndrome in China from 2010 to 2020, the age group (, ) was 9 (2, 40) years old, with 83 773 cases (43.8%) in the <5 years old group. There were 113 660 males, with a male-to-female ratio of 1.5∶1.0. There were as many as 105 508 cases (55.2%) of scattered children and preschool children. About 70 565 cases (36.9%) lived in the northern region. There were 13 858 HRSV positive cases, with a total positive rate of 7.2%. The positive rate of HRSV detection in the northern population was 5.7% (4 004/70 565), which was lower than that in the southern population (8.2%, 9 854/120 876), and the difference was statistically significant (χ=407.4, <0.001). HRSV was detected in all age groups, with the highest positive rate of 23.9% in the <6 months age group. The month with the highest positive rate was December, and autumn and winter were the main epidemic seasons. Both northern and southern HRSV subtypes were mainly infected with type A, with a low proportion of mixed infections of type A and type B. HRSV is a common pathogen causing respiratory infections in children from 2010 to 2020. It can be detected throughout the year and shows the main peak of prevalence in autumn and winter. The HRSV strain is mainly classified as a type A infection.
分析2010年至2020年中国发热性呼吸综合征病例中人类呼吸道合胞病毒（HRSV）的流行病学特征。基于传染病防控国家科技重大专项子课题“传染病监测技术平台”，于2010年1月至2020年12月在中国31个省（不包括香港、澳门和中国台湾）的哨点医院对发热性呼吸综合征病例进行主动监测，共纳入191441例病例。对监测病例的临床标本进行HRSV核酸筛查，采用χ²检验/ Fisher确切概率法分析不同年龄组、地区和时间段HRSV检出率的差异。在2010年至2020年中国191441例发热性呼吸综合征病例中，年龄中位数为9（2，40）岁，<5岁组有83773例（43.8%）。男性113660例，男女比例为1.5∶1.0。散居儿童和学龄前儿童多达105508例（55.2%）。约70565例（36.9%）居住在北方地区。HRSV阳性病例13858例，总阳性率为7.2%。北方人群HRSV检出率为5.7%（4004/70565），低于南方人群（8.2%，9854/120876），差异有统计学意义（χ² = 407.4，P < 0.001）。各年龄组均检测到HRSV，<6月龄组阳性率最高，为23.9%。阳性率最高的月份为12月，秋冬为主要流行季节。北方和南方的HRSV亚型均以A型感染为主，A、B型混合感染比例较低。2010年至2020年，HRSV是引起儿童呼吸道感染的常见病原体。全年均可检出，秋冬呈现流行高峰。HRSV毒株主要为A型感染。
