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PD-1 和 PD-L1 轴在 COVID-19 中的作用。

Role of the PD-1 and PD-L1 axis in COVID-19.

机构信息

Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.

Institute for Human Infections & Immunity, Sealy Institute for Vaccine Sciences, University of Texas Medical Branch, Galveston, TX 77555, USA.

出版信息

Future Microbiol. 2022 Sep;17:985-988. doi: 10.2217/fmb-2022-0103. Epub 2022 Jul 28.

DOI:10.2217/fmb-2022-0103
PMID:35899493
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9332906/
Abstract

Tweetable abstract Severe COVID-19 patients display dysregulated expression of checkpoint molecules PD-1 and its ligand PD-L1, suggesting that these checkpoint molecules could be considered as prognostic markers and therapeutic targets in severe cases of COVID-19.

摘要

摘要可发推

严重 COVID-19 患者表现出检查点分子 PD-1 及其配体 PD-L1 的失调表达，表明这些检查点分子可被视为 COVID-19 重症病例的预后标志物和治疗靶点。

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