Millar A B, Fromson B, Strickland B A, Denison D M
Thorax. 1986 Dec;41(12):932-9. doi: 10.1136/thx.41.12.932.
Twelve patients with chronic airflow limitation and 12 patients with a histological diagnosis of fibrosing alveolitis were studied. The calculated mean (SD) tissue volume of a single lung at total lung capacity was 467 (91) ml in the patients with alveolitis, which was 43% (14%) more than predicted for healthy people of the same age, sex, and height. The tissue volume of a single lung at total lung capacity was 436 (82) ml in the patients with chronic airflow limitation, which was 26% (21%) more than predicted. At residual volumes the tissue contents of the fibrotic and the obstructed lungs changed very little (to 407 (84) ml and 433 (84) ml respectively). This allowed tissue volume to be used as a marker of position within the lung, to match inspiratory and expiratory slices and to calculate regional ventilation. In both groups local ventilation was diminished and more variable than in healthy lungs--that is, in the mid 70% of lung volume the local residual volume to total gas volume ratios (RV/TGV) were 32% (10%) in the fibrotic group and 66% (14%) in the group with chronic airflow limitation, compared with 23% (5%) in healthy subjects. As expected, the fibrotic lungs were much denser (0.246 (0.036) g/ml) and the lungs with chronic airflow obstruction were less dense (0.114 (0.026) g/ml) than were healthy lungs (0.126 (0.017) g/ml).
对12例慢性气流受限患者和12例经组织学诊断为肺纤维化肺泡炎的患者进行了研究。肺泡炎患者在肺总量时单肺的计算平均（标准差）组织体积为467（91）ml，比相同年龄、性别和身高的健康人预测值多43%（14%）。慢性气流受限患者在肺总量时单肺的组织体积为436（82）ml，比预测值多26%（21%）。在残气量时，纤维化肺和阻塞性肺的组织含量变化很小（分别为407（84）ml和433（84）ml）。这使得组织体积可作为肺内位置的标志物，用于匹配吸气和呼气层面并计算局部通气。两组的局部通气均减少且比健康肺更具变异性——即，在肺容积的中70%，纤维化组的局部残气量与总气体量之比（RV/TGV）为32%（10%），慢性气流受限组为66%（14%），而健康受试者为23%（5%）。正如预期的那样，纤维化肺的密度更高（0.246（0.036）g/ml），慢性气流阻塞肺的密度低于健康肺（0.126（0.017）g/ml），为0.114（0.026）g/ml。
