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具有远程空间电荷转移效应的远红色荧光探针的简易获取方法,用于小鼠脑血管系统的体内双光子显微镜成像。

Facile Access to Far-Red Fluorescent Probes with Through-Space Charge-Transfer Effects for In Vivo Two-Photon Microscopy of the Mouse Cerebrovascular System.

机构信息

College of Chemistry and Materials Science, Jinan University, Guangzhou, 510632, China.

State Key Laboratory of Modern Optical Instrumentations, Centre for Optical and Electromagnetic Research, College of Optical Science and Engineering, International Research Center for Advanced Photonics, Zhejiang University, Hangzhou, 310058, China.

出版信息

Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202209590. doi: 10.1002/anie.202209590. Epub 2022 Aug 31.

DOI:10.1002/anie.202209590
PMID:35902377
Abstract

Much effort has been devoted to the generation of fluorescent probes by synthetic approaches. In this study, we developed a facile strategy to construct far-red fluorescent probes based on through-space charge transfer within complexes of acceptors and donors and their "twist+twist" interactions. Owing to their rare two-photon excitation property, the complexes could be used for in vivo imaging of the mouse cerebrovascular system.

摘要

人们已经投入了大量精力通过合成方法来产生荧光探针。在这项研究中,我们开发了一种基于受体和供体之间的通过空间电荷转移以及它们的“扭曲+扭曲”相互作用的复合物来构建远红色荧光探针的简便策略。由于它们罕见的双光子激发特性,这些复合物可用于小鼠脑血管系统的体内成像。

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