输血后免疫性血小板减少症。病例报告。

Posttransfusional immunologic thrombocytopenia. A case report.

作者信息

Soulier J P, Patereau C, Gobert N, Achach P, Muller J Y

出版信息

Vox Sang. 1979;37(1):21-9. doi: 10.1111/j.1423-0410.1979.tb02264.x.

DOI:10.1111/j.1423-0410.1979.tb02264.x

Abstract

A case of posttransfusional immunologic thrombocytopenia is reported in a 75-year-od PlA1-negative woman. This was the second episode of postoperative and posttransfusion thrombocytopenia in the same patient who had had only one pregnancy. Both thrombocytopenic episodes were subclinical and discovered by systematical hematologic study. A potent anti-PlA1-antibody (titer 1/128) was demonstrated by the platelet-indirect radioactive Coombs test which appeared more sensitive than other platelet immunological assays used. The very long duration of the thrombocytopenia is discussed as well as the therapeutic possibilities in such cases.

摘要

报道了一名75岁的PlA1阴性女性发生输血后免疫性血小板减少症的病例。这是该仅孕产过一次的患者术后及输血后血小板减少的第二次发作。两次血小板减少发作均为亚临床型，通过系统血液学检查发现。血小板间接放射性库姆斯试验证实存在高效抗PlA1抗体（效价1/128），该试验似乎比所使用的其他血小板免疫学检测更敏感。文中讨论了血小板减少症的极长病程以及此类病例的治疗可能性。