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输血后免疫性血小板减少症。病例报告。

Posttransfusional immunologic thrombocytopenia. A case report.

作者信息

Soulier J P, Patereau C, Gobert N, Achach P, Muller J Y

出版信息

Vox Sang. 1979;37(1):21-9. doi: 10.1111/j.1423-0410.1979.tb02264.x.

DOI:10.1111/j.1423-0410.1979.tb02264.x
PMID:573935
Abstract

A case of posttransfusional immunologic thrombocytopenia is reported in a 75-year-od PlA1-negative woman. This was the second episode of postoperative and posttransfusion thrombocytopenia in the same patient who had had only one pregnancy. Both thrombocytopenic episodes were subclinical and discovered by systematical hematologic study. A potent anti-PlA1-antibody (titer 1/128) was demonstrated by the platelet-indirect radioactive Coombs test which appeared more sensitive than other platelet immunological assays used. The very long duration of the thrombocytopenia is discussed as well as the therapeutic possibilities in such cases.

摘要

报道了一名75岁的PlA1阴性女性发生输血后免疫性血小板减少症的病例。这是该仅孕产过一次的患者术后及输血后血小板减少的第二次发作。两次血小板减少发作均为亚临床型,通过系统血液学检查发现。血小板间接放射性库姆斯试验证实存在高效抗PlA1抗体(效价1/128),该试验似乎比所使用的其他血小板免疫学检测更敏感。文中讨论了血小板减少症的极长病程以及此类病例的治疗可能性。

相似文献

1
Posttransfusional immunologic thrombocytopenia. A case report.输血后免疫性血小板减少症。病例报告。
Vox Sang. 1979;37(1):21-9. doi: 10.1111/j.1423-0410.1979.tb02264.x.
2
Posttransfusion purpura associated with an autoantibody directed against a previously undefined platelet antigen.与针对一种先前未明确的血小板抗原的自身抗体相关的输血后紫癜。
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Nomifensine-induced immune hemolytic anemia and posttransfusion purpura in the same patient.诺米芬辛在同一患者中引发免疫性溶血性贫血和输血后紫癜。
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Posttransfusion purpura: conversion of PLA1-negative platelets to the PLA1-positive phenotype by stored plasma is not due to the presence of soluble PLA1 antigen.输血后紫癜:储存血浆将PLA1阴性血小板转变为PLA1阳性表型并非由于可溶性PLA1抗原的存在。
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Post-transfusion purpura associated with alloimmunization against the platelet-specific antigen, Baka.与针对血小板特异性抗原Baka的同种免疫相关的输血后紫癜
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[Prospective diagnostic status of immunologic thrombocytopenia].[免疫性血小板减少症的前瞻性诊断状况]
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Posttransfusion purpura. Case report with observation on antibody detection and therapy.输血后紫癜。病例报告及抗体检测与治疗观察
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[Posttransfusion thrombocytopenic purpura. 1st case described in Spain].[输血后血小板减少性紫癜。西班牙报道的首例病例]
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Identification of the platelet alloantigen (PlA1) in circulating immune complexes of normal human sera.正常人血清循环免疫复合物中血小板同种抗原(PlA1)的鉴定。
Cancer Immunol Immunother. 1982;13(1):44-7. doi: 10.1007/BF00200199.