Januário Eric Vieira, Melo Samanta Rios, Maria Durvanei Augusto, Lorigados Carla Aparecida Batista, Ambrósio Aline Magalhães, Kogika Marcia Mery, Cogliati Bruno, Shimozako Helio Junji, Matera Julia Maria
Department of Surgery, School of Veterinary Medicine and Animal Science, University of São Paulo (FMVZ-USP), São Paulo, Brazil.
Laboratory of Development and Innovation, Institute Butantan, Butantan, São Paulo, Brazil.
Front Vet Sci. 2022 Jul 12;9:898077. doi: 10.3389/fvets.2022.898077. eCollection 2022.
Canine mast cell tumor is a malignant neoplasm, and a gold standard treatment remains to be determined despite the proposed chemotherapies or other therapies in dogs. This study aimed to determine therapeutic, adverse effects and toxicity, tumor-free, and overall survival times of 10 dogs with surgically excised mast cell tumors evaluated by histopathological/immunohistochemistry and treated with four weekly intravenous administrations of 2-Aminoethyl Dihydrogen Phosphate (70 mg/kg) as adjuvant therapy. No adverse events were noted. Laboratory changes were limited ( < 0.05) in red blood cell, hemoglobin, and platelet counts. Mean tumor-free and overall survival were 599.1 ± 469 and 755.5 ± 423.5 days, respectively. In conclusion, 2-Aminoethyl Dihydrogen Phosphate administration was safe in dogs. However, 2-Aminoethyl Dihydrogen Phosphate was not sufficiently effective to prevent a recurrence, new tumor, or metastasis of canine mast cell tumors with poor immunohistochemical prognostic factors.
犬肥大细胞瘤是一种恶性肿瘤,尽管针对犬类提出了化疗或其他治疗方法,但金标准治疗方案仍有待确定。本研究旨在确定10只经手术切除肥大细胞瘤的犬的治疗效果、不良反应和毒性、无瘤生存期和总生存期,这些犬经组织病理学/免疫组织化学评估,并接受四周每周一次静脉注射磷酸二氢氨基乙酯(70 mg/kg)作为辅助治疗。未观察到不良事件。红细胞、血红蛋白和血小板计数的实验室变化有限(<0.05)。平均无瘤生存期和总生存期分别为599.1±469天和755.5±423.5天。总之,犬类使用磷酸二氢氨基乙酯是安全的。然而,对于免疫组织化学预后因素较差的犬肥大细胞瘤,磷酸二氢氨基乙酯在预防复发、新肿瘤或转移方面效果不足。