核凝聚物：对抗寄生虫免疫逃避的新靶点？ - Suppr

Nuclear Condensates: New Targets to Combat Parasite Immune Evasion?

作者信息

Luzak Vanessa

机构信息

Department of Physiological Chemistry, Biomedical Center, Ludwig-Maximilians-Universität München, Munich, Germany.

Institute of Experimental Parasitology, Department of Veterinary Sciences, Ludwig-Maximilians-Universität München, Munich, Germany.

出版信息

Front Cell Infect Microbiol. 2022 Jul 12;12:942200. doi: 10.3389/fcimb.2022.942200. eCollection 2022.

DOI:10.3389/fcimb.2022.942200

PMID:35903200

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9314548/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2744/9314548/67fb5f8e064e/fcimb-12-942200-g001.jpg

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RNA promotes the formation of spatial compartments in the nucleus.

Cell. 2021 Nov 11;184(23):5775-5790.e30. doi: 10.1016/j.cell.2021.10.014. Epub 2021 Nov 4.

Nucleolar release of rDNA repeats for repair involves SUMO-mediated untethering by the Cdc48/p97 segregase.

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Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes.

Nat Microbiol. 2021 Mar;6(3):289-300. doi: 10.1038/s41564-020-00833-4. Epub 2021 Jan 11.

TSA-seq reveals a largely conserved genome organization relative to nuclear speckles with small position changes tightly correlated with gene expression changes.

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Trends Parasitol. 2022 Jan;38(1):23-36. doi: 10.1016/j.pt.2021.07.012. Epub 2021 Aug 7.

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Trends Parasitol. 2004 Mar;20(3):117-21. doi: 10.1016/j.pt.2003.12.004.

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本文引用的文献

N-methyladenosine in poly(A) tails stabilize VSG transcripts.

Nature. 2022 Apr;604(7905):362-370. doi: 10.1038/s41586-022-04544-0. Epub 2022 Mar 30.

An assembly of nuclear bodies associates with the active VSG expression site in African trypanosomes.

Nat Commun. 2022 Jan 10;13(1):101. doi: 10.1038/s41467-021-27625-6.

RNA promotes the formation of spatial compartments in the nucleus.

Cell. 2021 Nov 11;184(23):5775-5790.e30. doi: 10.1016/j.cell.2021.10.014. Epub 2021 Nov 4.

Nucleolar release of rDNA repeats for repair involves SUMO-mediated untethering by the Cdc48/p97 segregase.

Nat Commun. 2021 Aug 13;12(1):4918. doi: 10.1038/s41467-021-25205-2.

Nuclear compartmentalization as a mechanism of quantitative control of gene expression.

Nat Rev Mol Cell Biol. 2021 Oct;22(10):653-670. doi: 10.1038/s41580-021-00387-1. Epub 2021 Aug 2.

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TSA-seq reveals a largely conserved genome organization relative to nuclear speckles with small position changes tightly correlated with gene expression changes.

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Nuclear Condensates: New Targets to Combat Parasite Immune Evasion?

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