• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Masters of Disguise: Antigenic Variation and the VSG Coat in Trypanosoma brucei.

作者信息

Mugnier Monica R, Stebbins C Erec, Papavasiliou F Nina

机构信息

The Rockefeller University, Laboratory of Lymphocyte Biology, New York, New York, United States of America.

The Rockefeller University, Laboratory of Structural Microbiology, New York, New York, United States of America.

出版信息

PLoS Pathog. 2016 Sep 1;12(9):e1005784. doi: 10.1371/journal.ppat.1005784. eCollection 2016 Sep.

DOI:10.1371/journal.ppat.1005784
PMID:27583379
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5008768/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c4c/5008768/dc76e40bcbf3/ppat.1005784.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c4c/5008768/e4e7c315dbde/ppat.1005784.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c4c/5008768/dc76e40bcbf3/ppat.1005784.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c4c/5008768/e4e7c315dbde/ppat.1005784.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4c4c/5008768/dc76e40bcbf3/ppat.1005784.g002.jpg

相似文献

1
Masters of Disguise: Antigenic Variation and the VSG Coat in Trypanosoma brucei.伪装大师：布氏锥虫中的抗原变异与VSG被膜
PLoS Pathog. 2016 Sep 1;12(9):e1005784. doi: 10.1371/journal.ppat.1005784. eCollection 2016 Sep.
2
A Host-Pathogen Interaction Reduced to First Principles: Antigenic Variation in T. brucei.简化为基本原理的宿主-病原体相互作用：布氏锥虫的抗原变异
Results Probl Cell Differ. 2015;57:23-46. doi: 10.1007/978-3-319-20819-0_2.
3
Quantitative sequencing confirms VSG diversity as central to immune evasion by Trypanosoma brucei.定量测序证实，VSG多样性是布氏锥虫逃避免疫的核心所在。
Trends Parasitol. 2015 Aug;31(8):346-9. doi: 10.1016/j.pt.2015.05.001. Epub 2015 May 18.
4
Trypanosomes expressing a mosaic variant surface glycoprotein coat escape early detection by the immune system.表达嵌合型可变表面糖蛋白外壳的锥虫能够逃避免疫系统的早期检测。
Infect Immun. 2005 May;73(5):2690-7. doi: 10.1128/IAI.73.5.2690-2697.2005.
5
The in vivo dynamics of antigenic variation in Trypanosoma brucei.布氏锥虫抗原变异的体内动力学
Science. 2015 Mar 27;347(6229):1470-3. doi: 10.1126/science.aaa4502.
6
Antigenic diversity is generated by distinct evolutionary mechanisms in African trypanosome species.抗原多样性是由不同的进化机制在非洲锥虫物种中产生的。
Proc Natl Acad Sci U S A. 2012 Feb 28;109(9):3416-21. doi: 10.1073/pnas.1117313109. Epub 2012 Feb 13.
7
Ribonuclease H1-targeted R-loops in surface antigen gene expression sites can direct trypanosome immune evasion.核糖核酸酶 H1 靶向的表面抗原基因表达位点中的 R 环可指导锥虫免疫逃避。
PLoS Genet. 2018 Dec 13;14(12):e1007729. doi: 10.1371/journal.pgen.1007729. eCollection 2018 Dec.
8
Blocking Synthesis of the Variant Surface Glycoprotein Coat in Trypanosoma brucei Leads to an Increase in Macrophage Phagocytosis Due to Reduced Clearance of Surface Coat Antibodies.阻断布氏锥虫变异表面糖蛋白衣被的合成会导致巨噬细胞吞噬作用增加，原因是表面衣被抗体的清除减少。
PLoS Pathog. 2016 Nov 28;12(11):e1006023. doi: 10.1371/journal.ppat.1006023. eCollection 2016 Nov.
9
Antigenic variation in African trypanosomes: monitoring progress.非洲锥虫的抗原变异：进展监测
Trends Parasitol. 2004 Mar;20(3):117-21. doi: 10.1016/j.pt.2003.12.004.
10
Variant antigen diversity in Trypanosoma vivax is not driven by recombination.锥虫 vivax 变异抗原多样性不受重组驱动。
Nat Commun. 2020 Feb 12;11(1):844. doi: 10.1038/s41467-020-14575-8.

引用本文的文献

1
New tsetse (Glossina fuscipes fuscipes) genomes generated from wild and laboratory-reared specimens.从野生和实验室饲养的样本中获得的新的采采蝇（fuscipesfuscipes采采蝇）基因组。
Insect Sci. 2025 Jun 12. doi: 10.1111/1744-7917.70085.
2
TelAP2 links TelAP1 to the telomere complex in Trypanosoma brucei.在布氏锥虫中，TelAP2将TelAP1与端粒复合体相连。
Sci Rep. 2024 Dec 16;14(1):30493. doi: 10.1038/s41598-024-81972-0.
3
The actomyosin system is essential for the integrity of the endosomal system in bloodstream form .肌动球蛋白系统对于血液体形式的内体系统的完整性至关重要。

本文引用的文献

1
Trypanosoma brucei Parasites Occupy and Functionally Adapt to the Adipose Tissue in Mice.布氏锥虫寄生虫占据小鼠脂肪组织并在功能上适应该组织。
Cell Host Microbe. 2016 Jun 8;19(6):837-48. doi: 10.1016/j.chom.2016.05.002. Epub 2016 May 26.
2
How Does the VSG Coat of Bloodstream Form African Trypanosomes Interact with External Proteins?血流形式非洲锥虫的VSG外衣如何与外部蛋白质相互作用？
PLoS Pathog. 2015 Dec 31;11(12):e1005259. doi: 10.1371/journal.ppat.1005259. eCollection 2015 Dec.
3
A Host-Pathogen Interaction Reduced to First Principles: Antigenic Variation in T. brucei.
Elife. 2024 Nov 21;13:RP96953. doi: 10.7554/eLife.96953.
4
Continuous endosomes form functional subdomains and orchestrate rapid membrane trafficking in trypanosomes.连续内体形成功能亚结构域，并协调锥虫中的快速膜运输。
Elife. 2024 Apr 15;12:RP91194. doi: 10.7554/eLife.91194.
5
Protein lipidation in health and disease: molecular basis, physiological function and pathological implication.蛋白质脂质化在健康和疾病中的作用：分子基础、生理功能和病理意义。
Signal Transduct Target Ther. 2024 Mar 15;9(1):60. doi: 10.1038/s41392-024-01759-7.
6
Subtelomeric plasticity contributes to gene family expansion in the human parasitic flatworm Schistosoma mansoni.端粒外易位导致人类寄生扁虫曼氏血吸虫基因家族的扩张。
BMC Genomics. 2024 Feb 27;25(1):217. doi: 10.1186/s12864-024-10032-8.
7
A conserved trypanosomatid differentiation regulator controls substrate attachment and morphological development in Trypanosoma congolense.一个保守的锥虫分化调节因子控制着冈比亚锥虫中底物附着和形态发育。
PLoS Pathog. 2024 Feb 26;20(2):e1011889. doi: 10.1371/journal.ppat.1011889. eCollection 2024 Feb.
8
The intersection of host metabolism and immune responses to infection with kinetoplastid and apicomplexan parasites.宿主代谢与针对动基体目和顶复门寄生虫感染的免疫反应的交汇点。
Microbiol Mol Biol Rev. 2024 Mar 27;88(1):e0016422. doi: 10.1128/mmbr.00164-22. Epub 2024 Feb 1.
9
Unwrap RAP1's Mystery at Kinetoplastid Telomeres.揭开动基体端粒中 RAP1 的神秘面纱。
Biomolecules. 2024 Jan 4;14(1):67. doi: 10.3390/biom14010067.
10
Telomere maintenance in African trypanosomes.非洲锥虫中的端粒维持
Front Mol Biosci. 2023 Nov 24;10:1302557. doi: 10.3389/fmolb.2023.1302557. eCollection 2023.
简化为基本原理的宿主-病原体相互作用：布氏锥虫的抗原变异
Results Probl Cell Differ. 2015;57:23-46. doi: 10.1007/978-3-319-20819-0_2.
4
The in vivo dynamics of antigenic variation in Trypanosoma brucei.布氏锥虫抗原变异的体内动力学
Science. 2015 Mar 27;347(6229):1470-3. doi: 10.1126/science.aaa4502.
5
DNA double-strand breaks and telomeres play important roles in trypanosoma brucei antigenic variation.DNA双链断裂和端粒在布氏锥虫抗原变异中发挥重要作用。
Eukaryot Cell. 2015 Mar;14(3):196-205. doi: 10.1128/EC.00207-14. Epub 2015 Jan 9.
6
Capturing the variant surface glycoprotein repertoire (the VSGnome) of Trypanosoma brucei Lister 427.捕获布氏锥虫李斯特427株的可变表面糖蛋白库（VSG基因库）。
Mol Biochem Parasitol. 2014 Jun;195(1):59-73. doi: 10.1016/j.molbiopara.2014.06.004. Epub 2014 Jun 30.
7
Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control.非洲锥虫的抗原变异：染色体和核环境在 VSG 表达调控中的重要性。
Cell Microbiol. 2013 Dec;15(12):1984-93. doi: 10.1111/cmi.12215. Epub 2013 Oct 10.
8
Mosaic VSGs and the scale of Trypanosoma brucei antigenic variation.镶嵌型 VSG 与布氏锥虫抗原变异的规模。
PLoS Pathog. 2013;9(7):e1003502. doi: 10.1371/journal.ppat.1003502. Epub 2013 Jul 11.
9
Telomere length affects the frequency and mechanism of antigenic variation in Trypanosoma brucei.端粒长度影响布氏锥虫抗原变异的频率和机制。
PLoS Pathog. 2012;8(8):e1002900. doi: 10.1371/journal.ppat.1002900. Epub 2012 Aug 30.
10
Trypanosomal immune evasion, chronicity and transmission: an elegant balancing act.锥虫免疫逃避、慢性化和传播：一种巧妙的平衡行为。
Nat Rev Microbiol. 2012 Apr 30;10(6):431-8. doi: 10.1038/nrmicro2779.