Manganese Utilization in Pathogenesis: Beyond the Canonical Antioxidant Response.

The metal ion manganese (Mn) is equally coveted by hosts and bacterial pathogens. The host restricts Mn in the gastrointestinal tract and containing vacuoles, as part of a process generally known as nutritional immunity. serovar Typhimurium counteract Mn limitation using a plethora of metal importers, whose expression is under elaborate transcriptional and posttranscriptional control. Mn serves as cofactor for a variety of enzymes involved in antioxidant defense or central metabolism. Because of its thermodynamic stability and low reactivity, bacterial pathogens may favor Mn-cofactored metalloenzymes during periods of oxidative stress. This divalent metal catalyzes metabolic flow through lower glycolysis, reductive tricarboxylic acid and the pentose phosphate pathway, thereby providing energetic, redox and biosynthetic outputs associated with the resistance of to reactive oxygen species generated in the respiratory burst of professional phagocytic cells. Combined, the oxyradical-detoxifying properties of Mn together with the ability of this divalent metal cation to support central metabolism help colonize the mammalian gut and establish systemic infections.