Garcia Manriquez Bailey A, Kikis Elise A
Biology Department, The University of the South, Sewanee, Tennessee, USA.
MicroPubl Biol. 2022 Jul 21;2022. doi: 10.17912/micropub.biology.000613. eCollection 2022.
Vehicular air pollution is an environmental toxicant that can have several health consequences, such as decreased respiratory and cardiovascular function and an increased incidence of age-related dementia and neurodegenerative diseases such as Alzheimer's disease. has been previously shown to be a valuable animal model to study the effects of air pollution due to its tendency to respond to acute exposure to nano-sized particulate matter (nPM) produced by vehicular emissions. Specifically, nPM causes delayed development resulting in smaller animal size and induction of the SKN-1-mediated oxidative stress response. Here we show that various wild isolates demonstrate differential susceptibility to nPM, as measured by body size. Specifically, the Hawaiian isolate, CB4856, displayed the highest sensitivity, equivalent to its sensitivity to the potent oxidant paraquat. The findings described herein suggest that may be a useful genetic tool for identifying nPM-susceptibility loci.
车辆空气污染是一种环境毒物，可导致多种健康后果，如呼吸和心血管功能下降，以及与年龄相关的痴呆症和神经退行性疾病（如阿尔茨海默病）的发病率增加。此前已证明，由于其对车辆排放产生的纳米级颗粒物（nPM）急性暴露有反应的倾向，它是研究空气污染影响的一种有价值的动物模型。具体而言，nPM会导致发育延迟，从而使动物体型变小，并诱导SKN-1介导的氧化应激反应。在这里，我们表明，通过体型测量，各种野生分离株对nPM表现出不同的易感性。具体来说，夏威夷分离株CB4856表现出最高的敏感性，相当于其对强效氧化剂百草枯的敏感性。本文所述的研究结果表明，它可能是鉴定nPM易感性基因座的一种有用的遗传工具。
