钯（II）催化的内烯酰胺的对映选择性的分子间氧化二芳基化反应。
Palladium(II)-catalyzed enantioselective intermolecular oxidative diarylation of internal enamides.
机构信息
Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China.
出版信息
Chem Commun (Camb). 2022 Aug 16;58(66):9282-9285. doi: 10.1039/d2cc03202c.
The construction of vicinal stereogenic centers the simultaneous formation of two C-C bonds across alkenes under oxidative conditions is a stubborn challenge. Herein, we report a Pd(II)-catalyzed highly enantioselective intermolecular oxidative 1,2-diarylation reaction of internal enamides with aryl boronic acids, enabling the expedient construction of two vicinal stereocenters with excellent diastereo-, and enantioselectivities.
邻位立体中心的构建 在氧化条件下通过烯烃同时形成两个 C-C 键是一个棘手的挑战。在此，我们报告了一种 Pd(II)催化的内烯酰胺与芳基硼酸的高对映选择性的分子间氧化 1,2-二芳基化反应，能够有效地构建两个具有优异的非对映选择性和对映选择性的邻位立体中心。
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