Li M K, Shum D K, Choi S
Urol Res. 1987;15(2):75-7. doi: 10.1007/BF00260936.
The inhibitory activity of urine on calcium oxalate crystallization was measured as an inhibitory index using a gel model modified from Schneider et al. [8]. Urine samples from 36 recurrent stone formers and 21 controls in 3 separate periods (morning, afternoon and evening) were tested. Mean inhibitory indices of greater than 0 were observed among normal controls in the 3 sampled periods and among stone formers in the morning and afternoon samples. A significantly lower (negative) value was observed in the evening samples of stone formers, indicating a higher tendency towards crystallization than normal. The gel method may be applied to identify individuals at risk of stone formation if sufficient numbers of period-defined urine samples from the individual are tested for a statistically significant mean inhibitory index but whether this is practical in a clinical laboratory will need further evaluations.
采用经施耐德等人[8]改良的凝胶模型，以抑制指数来衡量尿液对草酸钙结晶的抑制活性。对36名复发性结石形成者和21名对照者在3个不同时间段（上午、下午和晚上）采集的尿液样本进行了检测。在3个采样时间段的正常对照者以及结石形成者上午和下午的样本中，均观察到平均抑制指数大于0。结石形成者晚上的样本中观察到显著较低（阴性）的值，表明其结晶倾向高于正常人。如果对个体足够数量的按时间段定义的尿液样本进行检测，以获得具有统计学意义的平均抑制指数，凝胶法可用于识别有结石形成风险的个体，但这在临床实验室是否可行还需要进一步评估。
