Post-Graduate Programme in Collective Health, University of Vale Do Rio Dos Sinos, Unisinos, Av. Unisinos, 950, Cristo Rei, São Leopoldo, RS, CEP 93022-750, Brazil.
Faculty of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Sleep Breath. 2023 Jun;27(3):1135-1142. doi: 10.1007/s11325-022-02672-5. Epub 2022 Jul 29.
To investigate the association between multimorbidity and sleep medication use in women.
A population-based cross-sectional study was conducted on women (20-69 years) in Southern Brazil. Sleep medications were identified using the Therapeutic and Chemical Anatomical Classification. Multimorbidity was operationalized according to two cutoff points: diagnosis of either two or more or three or more chronic conditions and presence or absence of obesity. Explanatory variables included sociodemographic, behavioral, and health factors including obesity and common mental disorders (CMD) (assessed using the Self-Reporting Questionnaire 20 for CMD). Crude and adjusted prevalence ratios (PR) and 95% confidence intervals (95%CIs) were estimated with Poisson regression with robust variance using various adjustment models.
In a sample of 1128 women, the prevalence of sleep medications was 14.3% (95%CI 12.2-16.3). After adjustments, the association between multimorbidity and sleep medication use yielded the following PR: multimorbidity ≥ 2:1.78 (95%CI, 1.23-2.56) and multimorbidity ≥ 3:1.90 (95%CI, 1.36-2.68). When obesity was included in the model, the effect was in the same direction but smaller, indicating that the presence of multimorbidity had an independent effect on the use of sleep medications, even after adjusting for CMD.
The presence of multimorbidity increased the probability of using sleep medications by approximately 80%, regardless of the observed cutoff point, inclusion of obesity in multimorbidity, and adjustment for CMD. Specific aspects of some chronic conditions may interfere with sleep quality, predisposing women to begin use of these medications at early ages and, consequently, to continue their use throughout later life.
研究女性多种疾病与睡眠药物使用之间的关联。
本研究为巴西南部一项基于人群的横断面研究,纳入 20-69 岁女性。使用治疗和化学解剖分类法识别睡眠药物。根据两种截断值来定义多种疾病:诊断出两种或更多或三种或更多的慢性疾病,以及存在或不存在肥胖。解释变量包括社会人口统计学、行为和健康因素,包括肥胖和常见精神障碍(CMD)(使用自我报告问卷 20 进行评估)。使用泊松回归分析具有稳健方差的各种调整模型,估计了粗患病率比(PR)和 95%置信区间(95%CI)。
在 1128 名女性样本中,睡眠药物的患病率为 14.3%(95%CI 12.2-16.3)。调整后,多种疾病与睡眠药物使用之间的关联得出以下 PR:多种疾病≥2:1.78(95%CI,1.23-2.56)和多种疾病≥3:1.90(95%CI,1.36-2.68)。当将肥胖纳入模型时,其作用方向相同,但幅度较小,表明即使在调整 CMD 后,多种疾病的存在对睡眠药物的使用仍有独立影响。
无论观察到的截断值如何,无论肥胖是否包含在多种疾病中,以及是否调整 CMD,存在多种疾病都会使使用睡眠药物的概率增加约 80%。某些慢性疾病的特定方面可能会影响睡眠质量,使女性在早期开始使用这些药物,并因此在以后的生活中继续使用。