School of Sports Health, HuBei University of Chinese Medicine, Wuhan, China.
School of Physical Education, Central China Normal University, Wuhan, China.
Medicine (Baltimore). 2022 Jul 29;101(30):e29917. doi: 10.1097/MD.0000000000029917.
There has never been a dose-response meta-analysis of the relationship between physical activity and the risk of depression. Hence, we aimed to explore the dose-response relationship between leisure-time physical activity (LTPA) and the risk of depression through a meta-analysis to provide a basis for the prevention of depression.
PubMed and Web of Science databases were searched using a computer to collect prospective cohort studies on the relationship between LTPA and depression between January 1997 and July 2021. A dose-response meta-analysis was performed using the Stata 14 software to calculate the combined effect size relative risk (RR and 95% confidence interval CI).
Twelve cohort studies included 310,359 subjects who met the inclusion criteria. The categorical dose-response analysis results showed that the risk of incident depression was 27%, 17%, and 8% lower for the light, moderate, and highest dose LTPA participants, respectively (RR: 0.73, 95% CI: 0.64-0.82; RR: 0.83, 95% CI: 0.78-0.87; RR: 0.92, 95% CI: 0.86-0.99), compared with the lowest LTPA category. Continuous dose-response analysis showed a nonlinear relationship between LTPA and the risk of incident depression (P = .04). The risk of incident depression was reduced by 3% (RR: 0.97, 95% CI: 0.95-0.98) for every 5 MET-h/week increase in LTPA < 25 MET-h/week; when LTPA was higher than 25 MET-h/week, a 4% increase in the risk of depression for every 5 MET-h/week increase was observed (RR: 1.04, 95% CI: 1.02-1.05).
There was a nonlinear relationship between LTPA and the risk of incident depression. Moderate and low doses of LTPA were protective factors in preventing the risk of incident depression, while high doses of LTPA may increase the risk of incident depression.
目前尚无关于体力活动与抑郁风险之间关系的剂量-反应荟萃分析。因此，我们旨在通过荟萃分析探讨休闲时间体力活动（LTPA）与抑郁风险之间的剂量-反应关系，为预防抑郁提供依据。
计算机检索 1997 年 1 月至 2021 年 7 月期间关于 LTPA 与抑郁关系的前瞻性队列研究，纳入 Pubmed 和 Web of Science 数据库。使用 Stata 14 软件进行剂量-反应荟萃分析，计算合并效应量相对风险（RR 和 95%置信区间 CI）。
共纳入 12 项队列研究，包含 310359 名符合纳入标准的研究对象。分类剂量-反应分析结果显示，轻、中、高剂量 LTPA 组的抑郁发生率分别降低 27%、17%和 8%（RR：0.73，95%CI：0.64-0.82；RR：0.83，95%CI：0.78-0.87；RR：0.92，95%CI：0.86-0.99），与最低 LTPA 组相比。连续剂量-反应分析显示，LTPA 与抑郁发生率之间存在非线性关系（P =.04）。LTPA 每增加 5MET-h/周，抑郁发生率降低 3%（RR：0.97，95%CI：0.95-0.98），LTPA ＜25MET-h/周；当 LTPA 高于 25MET-h/周时，每增加 5MET-h/周，抑郁发生率增加 4%（RR：1.04，95%CI：1.02-1.05）。
LTPA 与抑郁发生率之间存在非线性关系。中等和低剂量的 LTPA 是预防抑郁风险的保护因素，而高剂量的 LTPA 可能会增加抑郁风险。
