Department of Occupational Medicine, University of Navarra Clinic, Av. Pio XII, 36, 31008, Pamplona, Navarra, Spain.
Department of Preventive Medicine and Public Health, University of Navarra, Pamplona, Spain.
BMC Psychiatry. 2020 Mar 4;20(1):98. doi: 10.1186/s12888-020-02502-6.
An inverse association between total leisure-time physical activity (LTPA) and depression has been previously documented in the scientific literature. Our objective was to prospectively assess the association of LTPA with the risk of depression, focusing on several dimensions of LTPA (intensity, duration and type).
The SUN (Seguimiento Universidad de Navarra) project is a prospective cohort study formed by Spanish university graduates. A total of 15,488 adults (40.2% men, mean age 37 ± 12 years) initially free of depression were assessed. A report of a validated medical diagnosis of depression or the habitual use of antidepressants (any of both) were considered as incident cases of depression. LTPA was estimated through previously validated self-reported questionnaires. Participants were classified following Physical Activity recommendations from the World Health Organization, and according to the intensity, duration and type of LTPA. Cox proportional hazards regression models were run, adjusted for demographic, lifestyle, and dietary factors, to estimate adjusted hazard ratios (HR) of depression and 95% confidence intervals (CI).
During 163,059 person-years of follow-up we registered 870 incident cases of depression. Participants with higher total LTPA (METs-h/wk) and higher duration of LTPA (hours/wk) exhibited a lower risk of depression HR = 0.84 (95% CI: 0.72-0.99) and HR = 0.83 (0.70-0.99) respectively, whereas intensity of LTPA (MET) did not show any association with depression.
Participants with higher LTPA had a lower risk of depression. The inverse association was stronger for total LPTA time than for its intensity. Higher duration of LTPA should be encouraged to prevent depression.
既往研究表明，总休闲体力活动（LTPA）与抑郁之间呈负相关。本研究旨在前瞻性评估 LTPA 与抑郁风险之间的关联，并重点关注 LTPA 的几个维度（强度、时间和类型）。
SUN（纳瓦拉大学随访研究）是一项由西班牙大学毕业生组成的前瞻性队列研究。共有 15488 名成年人（40.2%为男性，平均年龄 37±12 岁），最初无抑郁病史。将经医学诊断证实的抑郁症或习惯性使用抗抑郁药（两者中的任何一种）的报告视为抑郁症的新发病例。LTPA 通过之前经过验证的自我报告问卷进行评估。参与者根据世界卫生组织的体力活动建议和 LTPA 的强度、时间和类型进行分类。采用 Cox 比例风险回归模型，调整人口统计学、生活方式和饮食因素，估计抑郁的调整后风险比（HR）和 95%置信区间（CI）。
在 163059 人年的随访期间，我们共登记了 870 例新发抑郁症病例。总 LTPA（METs-h/wk）和 LTPA 时间（小时/wk）较高的参与者患抑郁症的风险较低（HR=0.84，95%CI：0.72-0.99 和 HR=0.83，0.70-0.99），而 LTPA 强度（MET）与抑郁症无任何关联。
LTPA 较高的参与者患抑郁症的风险较低。总 LTPA 时间与抑郁症的负相关性强于 LTPA 强度。应鼓励增加 LTPA 的时间以预防抑郁症。
