Bölük Aydın, Yavuz Mervenur, Demircan Turan
School of Medicine, Muğla Sıtkı Koçman University, Muğla, Turkey.
Institute of Health Sciences, Muğla Sıtkı Koçman University, Muğla, Turkey.
Dev Dyn. 2022 Dec;251(12):1914-1933. doi: 10.1002/dvdy.520. Epub 2022 Aug 15.
The regenerative capacity varies significantly among the animal kingdom. Successful regeneration program in some animals results in the functional restoration of tissues and lost structures. Among the highly regenerative animals, axolotl provides multiple experimental advantages with its many extraordinary characteristics. It has been positioned as a regeneration model organism due to its exceptional renewal capacity, including the internal organs, central nervous system, and appendages, in a scar-free manner. In addition to this unique regeneration ability, the observed low cancer incidence, its resistance to carcinogens, and the reversing effect of its cell extract on neoplasms strongly suggest its usability in cancer research. Axolotl's longevity and efficient utilization of several anti-aging mechanisms underline its potential to be employed in aging studies.
动物界的再生能力差异显著。一些动物成功的再生过程能够实现组织和缺失结构的功能恢复。在高再生能力的动物中，蝾螈因其诸多非凡特性具有多种实验优势。由于其具有非凡的更新能力，包括以无瘢痕方式再生内部器官、中枢神经系统和附属肢体，它已被定位为一种再生模式生物。除了这种独特的再生能力外，观察到的低癌症发病率、对致癌物的抗性以及其细胞提取物对肿瘤的逆转作用，都有力地表明了它在癌症研究中的可用性。蝾螈的长寿以及对多种抗衰老机制的有效利用突出了其在衰老研究中的应用潜力。
