昼夜节律激素褪黑素在药物成瘾中的作用。

The roles of the circadian hormone melatonin in drug addiction.

机构信息

Guangdong Provincial Key Laboratory of Brain Connectome and Behavior, CAS Key Laboratory of Brain Connectome and Manipulation, Brain Cognition and Brain Disease Institute (BCBDI), Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, China; University of Chinese Academy of Sciences, Beijing, China.

Shenzhen Key Laboratory of Drug Addiction, Shenzhen Neher Neural Plasticity Laboratory, The Brain Cognition and Brain Disease Institute, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, Shenzhen, China; University of Chinese Academy of Sciences, Beijing, China.

出版信息

Pharmacol Res. 2022 Sep;183:106371. doi: 10.1016/j.phrs.2022.106371. Epub 2022 Jul 28.

DOI:10.1016/j.phrs.2022.106371

PMID:35907435

Abstract

Given the devastating social and health consequences of drug addiction and the limitations of current treatments, a new strategy is needed. Circadian system disruptions are frequently associated with drug addiction. Correcting abnormal circadian rhythms and improving sleep quality may thus be beneficial in the treatment of patients with drug addiction. Melatonin, an essential circadian hormone that modulates the biological clock, has anti-inflammatory, analgesic, anti-depressive, and neuroprotective effects via gut microbiota regulation and epigenetic modifications. It has attracted scientists' attention as a potential solution to drug abuse. This review summarized scientific evidence on the roles of melatonin in substance use disorders at the cellular, circuitry, and system levels, and discussed its potential applications as an intervention strategy for drug addiction.

摘要

鉴于药物成瘾带来的毁灭性社会和健康后果，以及当前治疗方法的局限性，我们需要新的策略。昼夜节律系统紊乱通常与药物成瘾有关。因此，纠正异常的昼夜节律和改善睡眠质量可能有益于治疗药物成瘾患者。褪黑素是一种调节生物钟的重要昼夜节律激素，通过调节肠道菌群和表观遗传修饰，具有抗炎、镇痛、抗抑郁和神经保护作用。它作为一种潜在的解决药物滥用问题的方法引起了科学家的关注。本综述总结了褪黑素在细胞、回路和系统水平上对物质使用障碍的作用的科学证据，并讨论了其作为药物成瘾干预策略的潜在应用。