Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China.
Shenyang Pharmaceutical University, No. 103, Wenhua Road, Shenyang 110016, China.
Int J Biol Macromol. 2022 Oct 31;219:545-557. doi: 10.1016/j.ijbiomac.2022.07.206. Epub 2022 Jul 28.
The loss of tissues and organs is a major challenge for biomedicine, and the emerging 3D bioprinting technology has brought the dawn for the development of tissue engineering and regenerative medicine. Chitosan-based supramolecular hydrogels, as novel biomaterials, are considered as ideal materials for 3D bioprinting due to their unique dynamic reversibility and fantastic biological properties. Although chitosan-based supramolecular hydrogels have wonderful biological properties, the mechanical properties are still under early exploration. This paper aims to provide some inspirations for researchers to further explore. In this review, common 3D bioprinting techniques and the properties required for bioink for 3D bioprinting are firstly described. Then, several strategies to enhance the mechanical properties of chitosan hydrogels are introduced from the perspectives of both materials and supramolecular binding motifs. Finally, current challenges and future opportunities in this field are discussed. The combination of chitosan-based supramolecular hydrogels and 3D bioprinting will hold promise for developing novel biomedical implants.
组织和器官的缺失是生物医学面临的主要挑战，新兴的 3D 生物打印技术为组织工程和再生医学的发展带来了曙光。壳聚糖基超分子水凝胶作为新型生物材料，由于其独特的动态可逆性和极好的生物学特性，被认为是 3D 生物打印的理想材料。尽管壳聚糖基超分子水凝胶具有极好的生物学特性，但机械性能仍处于早期探索阶段。本文旨在为研究人员提供进一步探索的启示。在这篇综述中，首先描述了常见的 3D 生物打印技术和 3D 生物打印生物墨水所需的特性。然后，从材料和超分子结合基序的角度介绍了几种增强壳聚糖水凝胶机械性能的策略。最后，讨论了该领域当前的挑战和未来的机遇。壳聚糖基超分子水凝胶与 3D 生物打印的结合将有望开发新型的生物医学植入物。
