洗必泰与中草药漱口水在牙周炎治疗中的作用。
Role of Chlorhexidine and Herbal Oral Rinses in Managing Periodontitis.
机构信息
Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
出版信息
Int Dent J. 2023 Apr;73(2):235-242. doi: 10.1016/j.identj.2022.06.027. Epub 2022 Jul 28.
OBJECTIVE
The aim of this research was to assess the effect of 0.12% chlorhexidine (CHX) and a Salvadora persica-based mouthwash on whole salivary tumour necrosis factor-alpha (TNF-α) levels and periodontal inflammation in patients with type 2 diabetes mellitus (T2DM).
METHODS
Patients with and without medically diagnosed T2DM were included. Patients' medical records were evaluated to confirm the diagnosis of T2DM. All patients underwent nonsurgical periodontal therapy (NSPT). Patients were divided into 2 subgroups. In the test and control group, patients were advised to rinse with an S persica-based mouthwash and a non-alcoholic 0.12% CHX after NSPT twice daily for 2 weeks, respectively. Demographic data were collected. Full-mouth plaque index (PI), gingival index (GI), probing depth (PD), and clinical attachment loss (AL) were measured, and whole salivary TNF-α levels were gauged at baseline and at 3-month follow-up. Haemoglobin A1c (HbA1c) levels were measured in all patients at baseline and at 3-month follow-up. Sample size estimation was done, and group comparison was performed. Level of significance was set at P < .01.
RESULTS
Twenty-one nondiabetic individuals and 21 patients with T2DM were included. At baseline, there was no significant difference in clinical and radiographic periodontal parameters amongst in patients with and without T2DM. At 3-month follow-up, HbA1c, TNF-α, PI, PD, and clinical AL were comparable with their respective baseline values in the test and control groups amongst patients with T2DM. In nondiabetic individuals, there was a significant reduction in PI (P < .01), GI (P < .01), and PD (P < .01), and TNF-α (P < .01) at 3-month follow-up in the test and control groups compared with their respective baseline scores.
CONCLUSIONS
In the short term, NSPT with 0.12% CHX or S persica-based mouthwashes is more effective in reducing periodontal inflammation and whole salivary TNF-α levels in nondiabetic individuals than in patients with T2DM with periodontal inflammation.
目的
本研究旨在评估 0.12%洗必泰（CHX）和基于 Salvadora persica 的漱口水对 2 型糖尿病（T2DM）患者全唾液肿瘤坏死因子-α（TNF-α）水平和牙周炎症的影响。
方法
纳入了有或无经医学诊断的 T2DM 的患者。评估患者的病历以确认 T2DM 的诊断。所有患者均接受非手术牙周治疗（NSPT）。患者分为 2 个亚组。在试验组和对照组中，在 NSPT 后，患者分别被建议使用基于 S persica 的漱口水和非酒精性 0.12% CHX 每天漱口 2 次，持续 2 周。收集人口统计学数据。在基线和 3 个月随访时，测量全口菌斑指数（PI）、牙龈指数（GI）、探诊深度（PD）和临床附着丧失（AL），并测量全唾液 TNF-α水平。所有患者在基线和 3 个月随访时测量糖化血红蛋白 A1c（HbA1c）水平。进行了样本量估算，并进行了组间比较。设定显著性水平为 P <.01。
结果
纳入了 21 名非糖尿病个体和 21 名 T2DM 患者。在基线时，T2DM 患者与非 T2DM 患者的临床和影像学牙周参数之间没有显著差异。在 3 个月随访时，T2DM 患者的 HbA1c、TNF-α、PI、PD 和临床 AL 与试验组和对照组各自的基线值相当。在非糖尿病个体中，与各自的基线评分相比，试验组和对照组在 3 个月随访时的 PI（P <.01）、GI（P <.01）、PD（P <.01）和 TNF-α（P <.01）均显著降低。
结论
在短期内，与基于 S persica 的漱口水相比，NSPT 联合 0.12% CHX 更能有效降低非糖尿病个体的牙周炎症和全唾液 TNF-α水平，而对伴有牙周炎症的 T2DM 患者效果较差。
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