经颅直流电刺激促进任务特异性运动学习的神经机制。
Neural Mechanism Underlying Task-Specific Enhancement of Motor Learning by Concurrent Transcranial Direct Current Stimulation.
机构信息
Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, 200031, China.
University of Chinese Academy of Sciences, Beijing, 100049, China.
出版信息
Neurosci Bull. 2023 Jan;39(1):69-82. doi: 10.1007/s12264-022-00901-1. Epub 2022 Jul 30.
Abstract
The optimal protocol for neuromodulation by transcranial direct current stimulation (tDCS) remains unclear. Using the rotarod paradigm, we found that mouse motor learning was enhanced by anodal tDCS (3.2 mA/cm) during but not before or after the performance of a task. Dual-task experiments showed that motor learning enhancement was specific to the task accompanied by anodal tDCS. Studies using a mouse model of stroke induced by middle cerebral artery occlusion showed that concurrent anodal tDCS restored motor learning capability in a task-specific manner. Transcranial in vivo Ca imaging further showed that anodal tDCS elevated and cathodal tDCS suppressed neuronal activity in the primary motor cortex (M1). Anodal tDCS specifically promoted the activity of task-related M1 neurons during task performance, suggesting that elevated Hebbian synaptic potentiation in task-activated circuits accounts for the motor learning enhancement. Thus, application of tDCS concurrent with the targeted behavioral dysfunction could be an effective approach to treating brain disorders.
摘要
经颅直流电刺激（tDCS）的最佳方案仍不明确。我们通过转棒实验发现，在任务执行过程中而非执行前后给予阳极 tDCS（3.2 mA/cm）可增强小鼠的运动学习能力。双重任务实验表明，运动学习增强是与阳极 tDCS 伴随的任务特异性的。使用大脑中动脉闭塞诱导的中风小鼠模型的研究表明，同时给予阳极 tDCS 可特异性地恢复特定任务的运动学习能力。经颅活体 Ca 成像进一步表明，阳极 tDCS 可升高而阴极 tDCS 可抑制初级运动皮层（M1）中的神经元活动。阳极 tDCS 可在任务执行过程中特异性促进与任务相关的 M1 神经元的活动，这表明任务激活回路中增强的赫布突触增强可解释运动学习的增强。因此，在靶向行为障碍的同时应用 tDCS 可能是治疗脑部疾病的有效方法。
相似文献
1
Neural Mechanism Underlying Task-Specific Enhancement of Motor Learning by Concurrent Transcranial Direct Current Stimulation.经颅直流电刺激促进任务特异性运动学习的神经机制。
Neurosci Bull. 2023 Jan;39(1):69-82. doi: 10.1007/s12264-022-00901-1. Epub 2022 Jul 30.
2
Transcranial direct-current stimulation combined with attention increases cortical excitability and improves motor learning in healthy volunteers.经颅直流电刺激联合注意提高健康志愿者皮质兴奋性和运动学习能力。
J Neuroeng Rehabil. 2020 Feb 19;17(1):23. doi: 10.1186/s12984-020-00665-7.
3
Effects of anodal transcranial direct current stimulation over lower limb primary motor cortex on motor learning in healthy individuals.经颅直流电刺激下肢初级运动皮层对健康个体运动学习的影响。
Eur J Neurosci. 2018 Apr;47(7):779-789. doi: 10.1111/ejn.13866. Epub 2018 Mar 6.
4
Transcranial direct current stimulation in stroke - Motor excitability and motor function.经颅直流电刺激治疗脑卒中——运动兴奋性和运动功能。
Clin Neurophysiol. 2022 Dec;144:16-22. doi: 10.1016/j.clinph.2022.09.003. Epub 2022 Sep 17.
5
Failure of tDCS to modulate motor excitability and speech motor learning.经颅直流电刺激未能调节运动兴奋性和言语运动学习。
Neuropsychologia. 2020 Sep;146:107568. doi: 10.1016/j.neuropsychologia.2020.107568. Epub 2020 Jul 18.
6
Adaptive threshold hunting for the effects of transcranial direct current stimulation on primary motor cortex inhibition.经颅直流电刺激对初级运动皮层抑制作用的自适应阈值探寻
Exp Brain Res. 2018 Jun;236(6):1651-1663. doi: 10.1007/s00221-018-5250-2. Epub 2018 Apr 2.
7
Non-linear effects of cathodal transcranial direct current stimulation (tDCS) of the primary motor cortex on implicit motor learning.初级运动皮层阴极经颅直流电刺激（tDCS）对内隐运动学习的非线性效应
Exp Brain Res. 2019 Apr;237(4):919-925. doi: 10.1007/s00221-019-05477-3. Epub 2019 Jan 19.
8
Enhanced motor learning following task-concurrent dual transcranial direct current stimulation.任务并发双经颅直流电刺激后运动学习增强
PLoS One. 2013 Dec 23;8(12):e85693. doi: 10.1371/journal.pone.0085693. eCollection 2013.
9
Excitability modulation of the motor system induced by transcranial direct current stimulation: a multimodal approach.经颅直流电刺激诱导运动系统的兴奋性调节：一种多模态方法。
Neuroimage. 2013 Dec;83:569-80. doi: 10.1016/j.neuroimage.2013.06.076. Epub 2013 Jul 9.
10
Priming the Motor Cortex With Anodal Transcranial Direct Current Stimulation Affects the Acute Inhibitory Corticospinal Responses to Strength Training.经颅直流电刺激运动皮层预处理对力量训练的急性抑制性皮质脊髓反应的影响。
J Strength Cond Res. 2019 Feb;33(2):307-317. doi: 10.1519/JSC.0000000000002959.
引用本文的文献
1
Resolving inconsistent effects of tDCS on learning using a homeostatic structural plasticity model.使用稳态结构可塑性模型解决经颅直流电刺激（tDCS）对学习的不一致影响。
Front Netw Physiol. 2025 Jul 7;5:1565802. doi: 10.3389/fnetp.2025.1565802. eCollection 2025.
2
Effects of noninvasive brain stimulation on motor functions in animal models of ischemia and trauma in the central nervous system.非侵入性脑刺激对中枢神经系统缺血和创伤动物模型运动功能的影响。
Neural Regen Res. 2026 Apr 1;21(4):1264-1276. doi: 10.4103/NRR.NRR-D-24-01613. Epub 2025 Jun 19.
3
Transcranial electrical stimulation (TES) in human motor Optimization: Mechanisms, safety, and emerging applications.人类运动优化中的经颅电刺激（TES）：机制、安全性及新兴应用
Biochem Biophys Rep. 2025 Jun 2;43:102055. doi: 10.1016/j.bbrep.2025.102055. eCollection 2025 Sep.
4
A wearable repetitive transcranial magnetic stimulation device.一种可穿戴式重复经颅磁刺激设备。
Nat Commun. 2025 Mar 19;16(1):2731. doi: 10.1038/s41467-025-58095-9.
5
Implicit Motor Learning Under Anodal or Cathodal tDCS During fMRI Induces Partially Distinct Network Responses.功能磁共振成像期间，阳极或阴极经颅直流电刺激下的内隐运动学习诱导出部分不同的网络反应。
Eur J Neurosci. 2025 Mar;61(5):e70053. doi: 10.1111/ejn.70053.
6
Efficacy observation of combined transcutaneous vagus nerve stimulation and transcranial direct current stimulation on gait in 169 subacute stroke patients.联合经皮迷走神经刺激和经颅直流电刺激对 169 例亚急性脑卒中患者步态的疗效观察。
J Rehabil Med. 2024 Nov 7;56:jrm40348. doi: 10.2340/jrm.v56.40348.
7
Right Frontal Gamma Transcranial Alternating Current Stimulation Modulates Optimism Biases.右侧额叶γ经颅交流电刺激调节乐观偏差。
Neurosci Bull. 2025 Jan;41(1):172-176. doi: 10.1007/s12264-024-01307-x. Epub 2024 Oct 19.
8
Research trends and hotspots of post-stroke upper limb dysfunction: a bibliometric and visualization analysis.脑卒中后上肢功能障碍的研究趋势与热点：文献计量学与可视化分析
Front Neurol. 2024 Oct 2;15:1449729. doi: 10.3389/fneur.2024.1449729. eCollection 2024.
9
Carotid artery transplantation of brain endothelial cells enhances neuroprotection and neurorepair in ischaemic stroke rats.脑内皮细胞颈动脉移植增强缺血性脑卒中大鼠的神经保护和神经修复作用。
Acta Pharmacol Sin. 2024 Dec;45(12):2487-2496. doi: 10.1038/s41401-024-01339-z. Epub 2024 Jul 11.
10
Effect of transcranial direct current stimulation with concurrent cognitive performance targeting posterior parietal cortex vs prefrontal cortex on working memory in schizophrenia: a randomized clinical trial.经颅直流电刺激联合靶向顶叶后皮质和前额皮质的认知表现对精神分裂症工作记忆的影响：一项随机临床试验。
Transl Psychiatry. 2024 Jul 8;14(1):279. doi: 10.1038/s41398-024-02994-w.
本文引用的文献
1
Effects of tDCS on the attentional blink revisited: A statistical evaluation of a replication attempt.经重复尝试的统计评估：tDCS 对注意瞬脱的影响。
PLoS One. 2022 Jan 27;17(1):e0262718. doi: 10.1371/journal.pone.0262718. eCollection 2022.
2
Cognitive functions and underlying parameters of human brain physiology are associated with chronotype.认知功能和人类大脑生理学的基础参数与昼夜节律类型有关。
Nat Commun. 2021 Aug 3;12(1):4672. doi: 10.1038/s41467-021-24885-0.
3
Low-frequency stimulation enhances ensemble co-firing and dexterity after stroke.低频刺激增强脑卒中后整体协同激发和灵活性。
Cell. 2021 Feb 18;184(4):912-930.e20. doi: 10.1016/j.cell.2021.01.023. Epub 2021 Feb 10.
4
Evidence-Based Guidelines and Secondary Meta-Analysis for the Use of Transcranial Direct Current Stimulation in Neurological and Psychiatric Disorders.基于证据的指南和二次荟萃分析用于治疗神经和精神疾病的经颅直流电刺激。
Int J Neuropsychopharmacol. 2021 Apr 21;24(4):256-313. doi: 10.1093/ijnp/pyaa051.
5
Different Therapeutic Effects of Transcranial Direct Current Stimulation on Upper and Lower Limb Recovery of Stroke Patients with Motor Dysfunction: A Meta-Analysis.经颅直流电刺激对运动功能障碍的脑卒中患者上下肢恢复的不同治疗效果：一项荟萃分析。
Neural Plast. 2019 Nov 16;2019:1372138. doi: 10.1155/2019/1372138. eCollection 2019.
6
Can Transcranial Direct-Current Stimulation Alone or Combined With Cognitive Training Be Used as a Clinical Intervention to Improve Cognitive Functioning in Persons With Mild Cognitive Impairment and Dementia? A Systematic Review and Meta-Analysis.单独或联合认知训练的经颅直流电刺激能否作为一种临床干预措施来改善轻度认知障碍和痴呆患者的认知功能？一项系统评价和荟萃分析。
Front Hum Neurosci. 2018 Oct 16;12:416. doi: 10.3389/fnhum.2018.00416. eCollection 2018.
7
Low-frequency cortical activity is a neuromodulatory target that tracks recovery after stroke.低频皮质活动是一种神经调制靶点，可跟踪中风后的恢复情况。
Nat Med. 2018 Aug;24(8):1257-1267. doi: 10.1038/s41591-018-0058-y. Epub 2018 Jun 18.
8
Functional organization of intrinsic and feedback presynaptic inputs in the primary visual cortex.初级视皮层中固有和反馈性突触前输入的功能组织。
Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5174-E5182. doi: 10.1073/pnas.1719711115. Epub 2018 May 14.
9
Studying and modifying brain function with non-invasive brain stimulation.用非侵入性脑刺激研究和修饰大脑功能。
Nat Neurosci. 2018 Feb;21(2):174-187. doi: 10.1038/s41593-017-0054-4. Epub 2018 Jan 8.
10
Transcranial electrical stimulation.经颅电刺激。
Curr Biol. 2017 Dec 4;27(23):R1258-R1262. doi: 10.1016/j.cub.2017.11.001.
Zotero 插件