Boston University, Boston, MA, 02215, USA.
ImagiRation, Boston, MA, 02135, USA.
J Autism Dev Disord. 2024 Sep;54(9):3533-3548. doi: 10.1007/s10803-023-06074-8. Epub 2023 Aug 16.
The purpose of this research was to investigate the impact of dietary factors on developmental trajectories in young autistic children.
A gluten-free and casein-free diets, as well as six types of food (meat and eggs, vegetables, uncooked vegetables, sweets, bread, and "white soft bread that never molds") were investigated observationally for up to three years in 5,553 children 2 to 5 years of age via parent-report measures completed within a mobile application. Children had a parent-reported diagnosis of Autism Spectrum Disorder (ASD); 78% were males; the majority of participants resided in the USA. Outcome was monitored on five orthogonal subscales: Language Comprehension, Expressive Language, Sociability, Sensory Awareness, and Health, assessed by the Autism Treatment Evaluation Checklist (ATEC) (Rimland & Edelson, 1999) and Mental Synthesis Evaluation Checklist (MSEC) (Arnold & Vyshedskiy, 2022; Braverman et al., 2018).
Consumption of fast-acting carbohydrates - sweets, bread, and "white soft bread that never molds" - was associated with a significant and a consistent Health subscale score decline. On the contrary, a gluten-free diet, as well as consumption of meat, eggs, and vegetables were associated with a significant and consistent improvement in the Language Comprehension score. Consumption of meat and eggs was also associated with a significant and consistent improvement in the Sensory Awareness score.
The results of this study demonstrate a strong correlation between a diet and developmental trajectories and suggest possible dietary interventions for young autistic children.
本研究旨在探讨饮食因素对自闭症儿童发育轨迹的影响。
通过家长报告的移动应用程序,对 5553 名 2 至 5 岁的儿童进行了为期三年的观察,研究了无麸质和无酪蛋白饮食以及六种食物(肉和蛋、蔬菜、生蔬菜、甜食、面包和“永远不会发霉的白色软面包”)。儿童有自闭症谱系障碍(ASD)的家长报告诊断;78%为男性;大多数参与者居住在美国。结果在五个正交分量表上进行监测:语言理解、表达语言、社交能力、感官意识和健康,由自闭症治疗评估检查表(ATEC)(Rimland 和 Edelson,1999)和心理综合评估检查表(MSEC)(Arnold 和 Vyshedskiy,2022;Braverman 等人,2018)评估。
快速作用碳水化合物(甜食、面包和“永远不会发霉的白色软面包”)的消耗与健康分量表评分的显著和持续下降有关。相反,无麸质饮食以及肉、蛋和蔬菜的摄入与语言理解分数的显著和持续提高有关。肉和蛋的摄入也与感官意识分数的显著和持续提高有关。
这项研究的结果表明饮食与发育轨迹之间存在很强的相关性,并为自闭症儿童提出了可能的饮食干预措施。