Faculty of Veterinary Medicine, University of Teramo, Teramo (TE) Italy.
Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle D'Aosta, National Reference Center of Veterinary and Comparative Oncology (CEROVEC), Genova, Italy.
J Equine Vet Sci. 2022 Oct;117:104087. doi: 10.1016/j.jevs.2022.104087. Epub 2022 Jul 29.
A 7-year-old Friesian stallion with a history of oesophageal stenosis, weight loss, inappetence, and recurrent hyperthermia was referred for gastroscopy. The stomach mucosa surrounding the oesophageal opening showed a large, necrotic, and ulcerated mass. On post-mortem examination, a very large, cauliflower-like neoplasm was seen, affecting non-glandular gastric mucosa. Nodular lesions were observed, scattered on the omentum, the spleen, and the liver. Microscopic findings allowed the diagnosis of gastric squamous cell carcinoma with abdominal metastasis. Biomolecular investigations demonstrated the presence of EcPV-2 genes in neoplastic lesions, thus supporting the role of EcPV-2 in the ethiology of equine gastric cancer.
一匹七岁的弗里斯马种公马，患有食管狭窄、体重减轻、食欲不振和反复发热的病史，被转介进行胃镜检查。食管开口周围的胃黏膜呈现出一个大的、坏死和溃疡性的肿块。在尸检时，发现一个非常大的、像菜花一样的肿瘤，影响非腺性胃黏膜。在大网膜、脾脏和肝脏上观察到结节性病变。显微镜检查结果诊断为胃鳞状细胞癌伴腹腔转移。生物分子研究表明，在肿瘤病变中存在 EcPV-2 基因，因此支持 EcPV-2 在马属动物胃癌发病机制中的作用。
