Adelson School of Medicine, Ariel University, Ariel 4077625, Israel; Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6905126, Israel.
Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 6905126, Israel.
Life Sci. 2022 Oct 1;306:120847. doi: 10.1016/j.lfs.2022.120847. Epub 2022 Jul 28.
Systemic, chronic, low-grade inflammation (SCLGI) underlies the pathogenesis of various widespread diseases. It is often associated with bone loss, thus connecting chronic inflammation to the pathogenesis of osteoporosis. In postmenopausal women, osteoporosis is accompanied by SCLGI development, likely owing to estrogen deficiency. We propose that SCGLI persistence in osteoporosis results from failed inflammation resolution, which is mainly mediated by specialized, pro-resolving mediators (SPMs). In corroboration, SPMs demonstrate encouraging therapeutic effects in various preclinical models of inflammatory disorders, including bone pathology. Since numerous data implicate gut dysbiosis in osteoporosis-associated chronic inflammation, restoring balanced microbiota by supplementing probiotics and prebiotics could contribute to the efficient resolution of SCGLI. In the present review, we provide evidence for this hypothesis and argue that efficient SCGLI resolution may serve as a novel approach for treating osteoporosis, complementary to traditional anti-osteoporotic medications.
全身性、慢性、低度炎症（SCLGI）是多种广泛疾病发病机制的基础。它通常与骨丢失有关，因此将慢性炎症与骨质疏松症的发病机制联系起来。在绝经后妇女中，骨质疏松症伴随着 SCLGI 的发展，可能是由于雌激素缺乏。我们提出，骨质疏松症中 SCLGI 的持续存在是由于炎症解决失败，这主要是由专门的、促解决介质（SPM）介导的。作为佐证，SPM 在各种炎症性疾病的临床前模型中表现出令人鼓舞的治疗效果，包括骨病理学。由于大量数据表明肠道菌群失调与骨质疏松症相关的慢性炎症有关，通过补充益生菌和益生元来恢复平衡的微生物群可能有助于有效解决 SCLGI。在本综述中，我们提供了这一假设的证据，并认为有效解决 SCLGI 可能是一种治疗骨质疏松症的新方法，可与传统的抗骨质疏松症药物互补。
