Yang Wu, Liu Tingting
Department of Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People's Republic of China.
Infect Drug Resist. 2022 Jul 23;15:3919-3925. doi: 10.2147/IDR.S371903. eCollection 2022.
Disseminated nocardiosis is a rare, life-threatening disease that usually found in immunocompromised patients, and is one of the most common causative pathogens. The difficulty in identifying the bacterium and the delay in initiating appropriate therapy often influence the prognosis of patients with disseminated nocardiosis. Here, we present a rare case of disseminated nocardiosis in a 61-year-old female with pulmonary fungus and secondary epilepsy. She received targeted antibiotic therapy and showed a great recovery in clinical symptoms and radiological signs. Disseminated nocardiosis can be easily overlooked due to the absence of characteristic symptoms and limitations of clinical examinations. Given the variability in antibiotic susceptibility patterns, the management of disseminated nocardiosis must be individualized. Therefore, early diagnosis and targeted antibiotic treatment are critical for the prognosis of disseminated nocardiosis.
播散性诺卡菌病是一种罕见的、危及生命的疾病，通常见于免疫功能低下的患者，是最常见的致病病原体之一。诺卡菌的鉴定困难以及开始适当治疗的延迟常常影响播散性诺卡菌病患者的预后。在此，我们报告一例61岁患有肺部真菌病和继发性癫痫的女性播散性诺卡菌病罕见病例。她接受了针对性抗生素治疗，临床症状和影像学征象有显著改善。由于缺乏特征性症状和临床检查的局限性，播散性诺卡菌病很容易被忽视。鉴于抗生素敏感性模式的变异性，播散性诺卡菌病的治疗必须个体化。因此，早期诊断和针对性抗生素治疗对播散性诺卡菌病的预后至关重要。
