Priya Sk Sujitha, Jha Ankita, Satish Kumar Rajappan Chandra, Sabarathinam Sarvesh
Department of Pharmacy Practice, SRM Institute of Science & Technology, Kattankulathur, Kancheepuram, 603203, Tamil Nadu, India.
Drug Testing Laboratory, Interdisciplinary Institute of Indian System of Medicine (IIISM), SRM Institute of Science & Technology, Kattankulathur, 603203, Tamil Nadu, India.
Future Sci OA. 2022 Jun 27;8(6):FSO803. doi: 10.2144/fsoa-2022-0020. eCollection 2022 Jul.
Guggulsterone, a phytosterol in the herb (Arn.) Bhandari, has been used in the treatment of diseases such as hyperlipidemia, arthritis and atherosclerosis. It has attracted significant research interest because of its pharmacological properties, especially its anti-inflammatory nature. It can be used for the treatment of inflammatory bowel disease (IBD), a disease characterized by chronic inflammation and damage in the gastrointestinal tract. In various preclinical studies, it inhibited NF-κB, an important pathway in the pathophysiology of IBD. This review summarizes the preclinical studies on this topic for providing more insights to the mechanism by which guggulsterone exerts its effect.
古古甾酮是一种存在于刺蒺藜（学名：Tribulus terrestris (L.) Bhandari）中的植物甾醇，已被用于治疗高脂血症、关节炎和动脉粥样硬化等疾病。由于其药理特性，尤其是抗炎性质，它引起了广泛的研究兴趣。它可用于治疗炎症性肠病（IBD），这是一种以胃肠道慢性炎症和损伤为特征的疾病。在各种临床前研究中，它抑制了核因子κB（NF-κB），这是IBD病理生理学中的一条重要途径。本综述总结了关于该主题的临床前研究，以便更深入了解古古甾酮发挥作用的机制。
