Yadav Arun Kumar, Ghosh S, Faujdar D S, Rajmohan K S, Bhalla Sharad, Shekhawat V S, Jindamwar Prashant, Dubey Sudhir, Sahai Atul, Rakesh C R, Chand Satish, Rawat M S, Gupta Shilpi, Dhawan Rakhi, Kotwal Atul, Bobdey Saurabh, Teli Prabhakar, Kaushik S K, Vaidya Rajesh
Associate Professor, Department of Community Medicine, Armed Forces Medical College, Pune, India.
Col AFMS (Health), O/o DGAFMS, New Delhi, India.
Med J Armed Forces India. 2022 Jul 19;80(3):270-5. doi: 10.1016/j.mjafi.2022.05.013.
The change in serological status of community may be used as input for guiding the public health policy. Hence, the present study was conducted to determine change in seroprevalence of COVID-19 among healthcare workers (HCWs).
From the baseline multicentric study sample, a subsample was followed up, and a seroepidemiological study was conducted among them between 6 and 22 weeks after the second dose of the vaccination. Multistage population proportion to size sampling was performed for the selection of subsample of HCWs. The serosurvey was conducted using the enzyme-linked immunosorbent assay-based IgG antibody test (COVID KAVACH).
Follow-up serological testing was done in subsample of 1122 participants of original 3253 participants. The mean age of the participants was 34.6 (8.13) years. A total of 300 (26.7%) participants were females. The seroprevalence was 78.52, (95%CI:76-80.1). Among those who were seronegative at initial test, 708 (77.04%) were seroconverted. Those who were not seroconverted (241 (21.5%)) have longer duration from the second dose of the vaccination (93 (31.4) vs. 56 (38.4); p value < 0.001). The COVID-19 infection was significantly associated with seropositive status and being a medical staff was associated with remaining seronegative on follow-up. The higher age (≥50 years) was found to be significantly associated with seroreversion.
Four in five HCWs had detectable antibodies. Seroepidemiological studies carry vital information to control the public health response in the course of the pandemic. The study can also further help as a platform to study the seroconversion and effect of vaccination among HCWs for newer variants of SARS-CoV-2.
社区血清学状态的变化可用作指导公共卫生政策的依据。因此，本研究旨在确定医护人员中新冠病毒病血清阳性率的变化。
从基线多中心研究样本中选取一个子样本进行随访，并在第二剂疫苗接种后6至22周对他们进行血清流行病学研究。采用多阶段按人口规模比例抽样方法选取医护人员子样本。血清学调查采用基于酶联免疫吸附测定的IgG抗体检测（新冠病毒抗体检测试剂盒）。
对原3253名参与者中的1122名参与者子样本进行了随访血清学检测。参与者的平均年龄为34.6（8.13）岁。共有300名（26.7%）参与者为女性。血清阳性率为78.52%，（95%置信区间：76%-80.1%）。在初次检测血清阴性的人中，708人（77.04%）发生了血清转化。未发生血清转化的人（241人（21.5%））从第二剂疫苗接种后经过的时间更长（93（31.4）天对56（38.4）天；p值<0.001）。新冠病毒感染与血清阳性状态显著相关，而作为医护人员与随访时血清仍为阴性相关。发现较高年龄（≥50岁）与血清逆转显著相关。
五分之四的医护人员有可检测到的抗体。血清流行病学研究为疫情期间控制公共卫生应对措施提供了重要信息。该研究还可进一步作为一个平台，用于研究医护人员中针对新冠病毒新变种的血清转化情况和疫苗效果。
