Costa Allysson, de Brito Gleisson A P
Laboratory of Physiology and Developmental Biology, Federal University of Latin American Integration-UNILA, Foz do Iguaçu, Paraná, Brazil.
J Nutr Metab. 2022 Jul 21;2022:3908675. doi: 10.1155/2022/3908675. eCollection 2022.
Several studies indicate that celiac disease patients present alterations within anthropometric, metabolic, and inflammatory parameters, while physical exercise and fish oil are known to activate modulatory pathways of such parameters.
To investigate the effects of a 12-week-long protocol of aerobic exercise and its association with fish oil supplementation in nineteen adult celiac disease patients. . The celiacs were divided into 2 groups: (A) FOS: supplementation ( = 11); and (B) EXE: supplementation and exercise ( = 8). The celiac groups were compared to the adult healthy control group (CTR) ( 12). Aerobic exercises were performed weekly, in three sessions of 60 minutes each, with a maximal heart rate intensity of 60-70%. The participants received 2 g/day of fish oil, a daily intake of 420 mg of eicosapentaenoic acid, and 230 mg of docosahexaenoic acid. The following measurements were taken in four phases: (A) anthropometry: body mass, height, body mass index, waist-to-hip ratio, fat mass, and fat-free mass; (B) metabolic profile: total cholesterol, triglycerides, HDL, and LDL; and (C) inflammatory profile: C-reactive protein and interleukin-6.
Supplementation associated with aerobic exercise promoted a significant reduction in C-reactive protein ( < 0.01) and increased the proportion of individuals in the undetectable range of interleukin-6.
The associated interventions showed a corrective and preventive potential in relation to disorders associated with chronic inflammation; however, the experimental design does not allow us to discriminate between the biological effects that are dependent on the association between interventions and those exclusively dependent on aerobic exercise.
多项研究表明，乳糜泻患者在人体测量、代谢和炎症参数方面存在改变，而体育锻炼和鱼油已知可激活这些参数的调节途径。
研究一项为期12周的有氧运动方案对19名成年乳糜泻患者的影响及其与补充鱼油的关联。将乳糜泻患者分为两组：(A) FOS组：补充剂组（n = 11）；(B) EXE组：补充剂和运动组（n = 8）。将乳糜泻组与成年健康对照组（CTR）（n = 12）进行比较。每周进行有氧运动，每次60分钟，共三次，最大心率强度为60 - 70%。参与者每天摄入2克鱼油，其中二十碳五烯酸每日摄入量为420毫克，二十二碳六烯酸每日摄入量为230毫克。在四个阶段进行以下测量：(A)人体测量学：体重、身高、体重指数、腰臀比、脂肪量和去脂体重；(B)代谢谱：总胆固醇、甘油三酯、高密度脂蛋白和低密度脂蛋白；(C)炎症谱：C反应蛋白和白细胞介素-6。
补充剂与有氧运动相结合可显著降低C反应蛋白（P < 0.01），并增加白细胞介素-6在不可检测范围内的个体比例。
相关干预措施在与慢性炎症相关的疾病方面显示出纠正和预防潜力；然而，实验设计不允许我们区分依赖于干预措施之间关联的生物学效应和仅依赖于有氧运动的生物学效应。
