Public Nutrition Department, Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile.
Corporación de Salud Municipal de Puente Alto, Santiago, Chile.
Front Public Health. 2022 Jul 14;10:904668. doi: 10.3389/fpubh.2022.904668. eCollection 2022.
Pregnancy is a critical developmental window in which optimal maternal nutrition and health are key for pregnancy and infant development. The COVID-19 pandemic is considered as a "natural experiment" in which maternal and infant nutrition and health challenges were faced especially in developing countries. Therefore, understanding the health consequences for mothers and infants living in the COVID-19 era is key to revisit public health measures focused on maternal and infant health. The current work aims to describe the design, methods, and descriptive information at recruitment and preliminary findings of the Chilean Maternal & Infant Cohort Study II (CHiMINCs-II) cohort.
The CHiMINCs-II is an ongoing cohort that is part of the Chilean Maternal and Infant Nutrition Observatory of the South-East area of Santiago, Chile. In total, 1954 pregnant women beneficiaries of the public health systems and their offspring were recruited before 15 weeks of gestation and are followed across pregnancy (<15, 26-28, and 35-37 weeks of gestation) and up to 2 years of age in their offspring. Two studies are currently nested within the CHiMINCs-II cohort: (1) Breast Cancer Risk Assessment in Mothers (BRECAM) study, and (2) the CHiMINCs-COVID study. The primary objective of BRECAM study is to test the association between maternal metabolic indicators (i.e., insulin, glucose, insulin growth factor 1, and hemoglobin A1c concentrations) at early pregnancy (i.e., <15 and 26-28 weeks of gestation) and breast density 3 months after the cessation of lactation. For this purpose, we collect maternal obstetric, lifestyle, dietary intake, anthropometric, and biochemical information. The aim of the CHiMINCs-COVID study is to assess maternal dietary intake and mental health problems derived from the COVID-19 pandemic and their association with maternal and infant's health and nutrition. Thus, we collected detailed information on dietary behaviors, mental health, and COVID-related information at each trimester, along with neonatal and infant nutritional information.
The findings of this study will provide novel and critical information to better understand maternal nutritional status, mental health, as well as infant growth and nutrition during the COVID-19 era.
BRECAM study registration number NCT03920098 and CHiMINCs-COVID study registration number NCT01916603.
妊娠是一个关键的发育窗口期，在此期间，孕产妇最佳营养和健康对于妊娠和婴儿发育至关重要。COVID-19 大流行被认为是一个“自然实验”，在此期间，发展中国家尤其面临孕产妇营养和健康方面的挑战。因此，了解生活在 COVID-19 时代的母婴健康后果对于重新审视关注母婴健康的公共卫生措施至关重要。本研究旨在描述智利母婴队列研究 II（CHiMINCs-II）的设计、方法和招募时的描述性信息以及初步研究结果。
CHiMINCs-II 是一个正在进行的队列研究，是智利圣地亚哥东南部母婴营养观察站的一部分。共有 1954 名受益于公共卫生系统的孕妇及其后代在妊娠 15 周前被招募，并在妊娠期间（<15、26-28 和 35-37 周）以及其后代 2 岁时进行随访。目前有两项研究嵌套在 CHiMINCs-II 队列中：（1）母亲乳腺癌风险评估研究（BRECAM）和（2）CHiMINCs-COVID 研究。BRECAM 研究的主要目的是检测妊娠早期（即<15 和 26-28 周）时母体代谢指标（即胰岛素、血糖、胰岛素生长因子 1 和血红蛋白 A1c 浓度）与哺乳期结束后 3 个月时乳房密度之间的关联。为此，我们收集了孕产妇产科、生活方式、饮食摄入、人体测量和生化信息。CHiMINCs-COVID 研究的目的是评估 COVID-19 大流行期间孕产妇的饮食摄入和心理健康问题及其与母婴健康和营养的关系。因此，我们在每个孕期收集了详细的饮食行为、心理健康和与 COVID 相关的信息，以及新生儿和婴儿的营养信息。
本研究的结果将提供新的和关键的信息，以更好地了解 COVID-19 时代母婴的营养状况、心理健康以及婴儿的生长和营养。
BRECAM 研究注册号 NCT03920098 和 CHiMINCs-COVID 研究注册号 NCT01916603。
