Mammari Nour, Krier Ysaline, Albert Quentin, Devocelle Marc, Varbanov Mihayl
L2CM, Université de Lorraine, CNRS, F-54000 Nancy, France.
Faculté de Pharmacie, 7 Avenue de la Foret de Haye, 54505 Vandoeuvre-Les-Nancy, France.
Pharmaceuticals (Basel). 2021 Aug 6;14(8):774. doi: 10.3390/ph14080774.
Numerous studies have led to a better understanding of the mechanisms of action of viruses in systemic infections for the development of prevention strategies and very promising antiviral therapies. Viruses still remain one of the main causes of human diseases, mainly because the development of new vaccines is usually challenging and drug resistance has become an increasing concern in recent decades. Therefore, the development of potential antiviral agents remains crucial and is an unmet clinical need. One abundant source of potential therapeutic molecules are plants: they biosynthesize a myriad of compounds, including peptides which can have antimicrobial activity. Our objective is to summarize the literature on peptides with antiviral properties derived from plants and to identify key features of these peptides and their application in systemic viral infections. This literature review highlights studies including clinical trials which demonstrated that plant cyclotides have the ability to inhibit the growth of viruses causing human diseases, defensin-like peptides possess anti-HIV-1 activity, and lipid transfer proteins and some lectins exhibit a varied antimicrobial profile. To conclude, plant peptides remain interesting to explore in the context of emerging and re-emerging infectious diseases.
众多研究有助于更深入地理解病毒在全身感染中的作用机制，从而制定预防策略并开发极具前景的抗病毒疗法。病毒仍然是人类疾病的主要病因之一，主要是因为新型疫苗的研发通常具有挑战性，且耐药性在近几十年来日益受到关注。因此，开发潜在的抗病毒药物仍然至关重要，且是一项尚未满足的临床需求。潜在治疗分子的一个丰富来源是植物：它们生物合成无数化合物，包括具有抗菌活性的肽。我们的目标是总结关于源自植物的具有抗病毒特性的肽的文献，并确定这些肽的关键特征及其在全身病毒感染中的应用。这篇文献综述重点介绍了包括临床试验在内的研究，这些研究表明植物环肽有能力抑制导致人类疾病的病毒生长，防御素样肽具有抗HIV-1活性，脂质转移蛋白和一些凝集素表现出多种抗菌特性。总之，在新发和再发传染病的背景下，植物肽仍是值得探索的研究对象。
