Liu Zhanglin, Sun Shengshu, Sun Xiaowen, Wu Yuan, Huang Yue
Tianjin Medical University Eye Hospital, Eye Institute and School of Optometry, Tianjin, China.
Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin, China.
Front Psychiatry. 2022 Jul 13;13:930714. doi: 10.3389/fpsyt.2022.930714. eCollection 2022.
This study aimed to investigate the association between dry eye disease (DED) and DED-related anxiety and depression tendencies, as well as the risk factors for anxiety and depression in patients with DED of different age groups. This was a cross-sectional study involving 160 patients with DED and 80 healthy individuals aged 20-65 years. All participants completed the investigation of the demographic characteristics, the Hospital Anxiety Depression Scale (HADS), the Ocular Surface Disease Index (OSDI) questionnaire, the Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire, and underwent objective clinical eye examinations. In patients aged 20-40 years, anxiety and depression scores were correlated with OSDI, sleep disorders, and Best Corrected Visual Acuity (BCVA). In patients with DED aged 41-65 years, anxiety scores were correlated with sleep disorders, the level of DED impact on life and work, and the severity of DED. Depression scores were correlated with sleep disorders and the severity of DED. The results indicated that the tendency for anxiety and depression was closely associated with DED and sleep disorders. Moreover, the factors affecting anxiety and depression in patients varied with age.
本研究旨在探讨干眼疾病（DED）与干眼相关焦虑和抑郁倾向之间的关联，以及不同年龄组干眼患者焦虑和抑郁的危险因素。这是一项横断面研究，纳入了160例干眼患者和80例年龄在20至65岁之间的健康个体。所有参与者均完成了人口统计学特征调查、医院焦虑抑郁量表（HADS）、眼表疾病指数（OSDI）问卷、干眼标准患者评估（SPEED）问卷，并接受了客观的临床眼部检查。在20至40岁的患者中，焦虑和抑郁评分与OSDI、睡眠障碍及最佳矫正视力（BCVA）相关。在41至65岁的干眼患者中，焦虑评分与睡眠障碍、干眼对生活和工作的影响程度以及干眼严重程度相关。抑郁评分与睡眠障碍和干眼严重程度相关。结果表明，焦虑和抑郁倾向与干眼及睡眠障碍密切相关。此外，影响患者焦虑和抑郁的因素随年龄而异。
