Samakar Bahareh, Mehri Soghra, Hosseinzadeh Hossein
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Iran J Basic Med Sci. 2022 May;25(5):543-553. doi: 10.22038/IJBMS.2022.58892.13079.
Metabolic syndrome is a serious health condition, yet a common worldwide disorder. It includes several risk factors such as hypertension, dyslipidemia, and high glucose levels which lead the patients to higher risks of cardiovascular diseases, diabetes, and stroke. Phytotherapy plays an important role in treating components of metabolic syndrome. Nettle () is considered a valuable plant due to bioactive compounds such as formic acid and rich sources of flavonoids. To acknowledge the role of nettle in metabolic syndrome, several mechanisms have been suggested such as alterations in potassium and calcium channels which improve hypertension. Antihyperlipidemic properties of nettle are mediated by inhibition of HMGCoA reductase and amelioration of lipid peroxidation via antioxidant effects. Also, one of the flavonoids in nettle, quercetin, is responsible for decreasing total cholesterol. Moreover, nettle is responsible for anti-diabetic effects through processes such as increasing insulin secretion and proliferation of pancreatic β-cells. This review aims to gather different studies to confirm the potential efficacy of nettle in metabolic syndrome.
代谢综合征是一种严重的健康状况，却是全球常见的疾病。它包括高血压、血脂异常和高血糖水平等多种风险因素，这些因素会使患者面临更高的心血管疾病、糖尿病和中风风险。植物疗法在治疗代谢综合征的各个组成部分中发挥着重要作用。荨麻（）由于含有甲酸等生物活性化合物以及丰富的黄酮类化合物来源，被认为是一种有价值的植物。为了认识荨麻在代谢综合征中的作用，人们提出了多种机制，如钾离子和钙离子通道的改变可改善高血压。荨麻的降血脂特性是通过抑制HMGCoA还原酶以及通过抗氧化作用改善脂质过氧化来介导的。此外，荨麻中的一种黄酮类化合物槲皮素负责降低总胆固醇。此外，荨麻通过增加胰岛素分泌和胰腺β细胞增殖等过程发挥抗糖尿病作用。本综述旨在收集不同的研究，以证实荨麻在代谢综合征中的潜在疗效。
